Bone Graft Substitutes Market

According to Stratistics MRC, the Global Bone Graft Substitutes Market is accounted for $3.86 billion in 2023 and is expected to reach $6.71 billion by 2030 growing at a CAGR of 8.2% during the forecast period. Bone grafts substitutes are substances used to fix fractures in the bones or replace missing bones. BGS is often used in surgeries for the hip, foot, and ankle, as well as for fractures and musculoskeletal ailments. The main purposes of employing bone grafts and replacements are to replace natural bone and to assist in the healing of fractures and other bone injuries. Bone graft replacements eliminate the need for extra surgical sites, shorten healing times, and lessen the risk of immunogenicity, disease transmission, and donor-site complications.

According to the Centers for Disease Control and Prevention (CDC) data in January 2021, 1 in 4 adults between 20-64 years of age suffer from at least one cavity, and almost 57% of adolescents aged 12-19 have had a hole in their permanent teeth.



Market Dynamics:

Driver:

Rise in the geriatric population

The democratization of high-risk sports and the aging of the population have increased the incidence of bone disorders and fractures. With age, the risk of spinal damage rises. Bones become porous and more prone to fractures as we age because bone mineral density diminishes. Bone graft alternatives aid in the quick healing of wounds in the elderly. The rise in occurrences of bone cancer is another factor driving demand for bone grafts and replacements. These factors are accelerating the market's expansion.

Restraint:

Restrictive regulatory environment

The market for alternatives to bone transplants is explicitly regulated and licensed in industrialized countries. Obtaining regulatory clearance for new products may be time-consuming and expensive. The market may be in danger if regulatory procedures change or if approvals take longer than expected. Due to technological limitations on product effectiveness, scalability, and manufacturing techniques, the development of bone graft substitutes may be hindered, which would prohibit the industry from expanding.

Opportunity:

Expanding R&D initiatives

Ongoing R&D initiatives to give different product offerings are one of the most well-liked developments in the worldwide industry. This growth in continuing R&D is brought on by the growing need for effective bone graft replacements for bone-related events, such as mild to severe fractures and trauma. There are attempts being conducted all around the world to create new uses for bone grafts in regenerative medicine. The market is also projected to expand as a consequence of several large companies' continued efforts to produce biodegradable polymeric materials and alternatives to bone grafts.

Threat:

High cost of raw materials

Bone graft substitutes are overpriced, as they are a long-term solution to bone disease treatment. No two patients, or their unique bone transplants and alternative therapies, are precisely same. As a result, there are differences in the number of appointments, processes, and expenses. A difficult poster lateral lumbar spine fusion bone transplant procedure costs thousands of dollars to perform. This element is impeding market expansion.

Covid-19 Impact

With fewer patients in hospitals and speciality clinics owing to the COVID-19 epidemic, replacements have been used less frequently. The pandemic caused major revenue drops for key firms in the bone graft replacements sector. The COVID-19 care-related limits put in place by the government reduced the frequency of patient visits and postponed elective procedures, which had an effect on the sales of these alternatives. In contrast, more people were admitted to hospitals in 2021 as a result of government rules being loosened. Most elective procedures involving the spine and trauma were carried out in hospitals. Such a return to surgical operations in 2021 had a favourable effect on demand for these substitutes.

The ceramic segment is expected to be the largest during the forecast period

The ceramic segment is estimated to have a lucrative growth. Due to its stability and longevity, the ceramic segment is rapidly gaining favour. Bone graft replacements help to maintain space and prevent collapse in load-bearing applications. Because of their porous porosity, ceramics are readily biodegradable and have strong osteoconductivity. The surrounding bone tissues develop and progressively proceed through bone replacement as a result of its introduction in vivo. These several elements support the segment's expansion.

The dental segment is expected to have the highest CAGR during the forecast period

The dental segment is anticipated to witness the fastest CAGR growth during the forecast period, due to the rising prevalence of periodontal and dental disorders including dental caries and dental cavities among the population. Bone graft replacements support strong biting function and stimulation of bone development. One out of every four dental implants requires bone grafting, which is the only way to stop the loss of dental bone. This surgery returns the jaw to its pre-injury state after tooth loss, gum disease, or trauma.

Region with largest share:

North America is projected to hold the largest market share during the forecast period owing to the rising geriatric population and increasing incidence of sports injuries & fatal accidents. In the region, the prevalence of joint-related illnesses such osteoarthritis, rheumatoid arthritis, and arthritis is on the rise. The acceptance of such items is also being aided by the region's well-established healthcare infrastructure, favourable reimbursement rules, and plenty of orthopedic surgeons who conduct operations involving bone transplants.

Region with highest CAGR:

Asia Pacific is projected to have the highest CAGR over the forecast period, owing to the surge in medical tourism and beneficial government policies. This region has huge geriatric population. With an increase in the geriatric population, there is a rise in the number of people suffering from various arthritis problems which increases the demand for bone grafting procedures. Furthermore, the presence of a larger patient pool with a range of orthopedic conditions, and rising investments by market participants to expand their presence in the region are expected to drive the market in Asia Pacific region.



Key players in the market

Some of the key players in Bone Graft Substitutes Market include AlloSource, Arthrex, Inc., Aziyo Biologics, Inc., Baxter International Inc., Bioventus LLC, Coloplast Corp., Integra LifeSciences Corporation, Johnson & Johnson, LifeNet Health, Medtronic, NuVasive, Inc., Olympus Corporation, Orthofix Medical Inc.,RTI Surgical Holdings, Inc., SeaSpine Holdings Corporation, Stryker Corporation, Wright Medical Group N.V., Xtant Medical, Holdings, Inc., Zimmer Biomet Holdings, Inc. and TBF Tissue Engineering.

Key Developments:

In May 2023, Zimmer Biomet Holdings, Inc. announced the launch of its VIVIX 3D Printed Bone Matrix, a breakthrough bone graft substitute with a porous structure designed to mimic the natural bone environment.

In April 2023, Stryker Corporation acquired NuVasive, Inc., a leading provider of spine surgery solutions, expanding its product portfolio in the bone graft substitutes market and strengthening its presence in the spine care segment.

In December 2022, Kuros Biosciences announced a collaboration with Johnson & Johnson Medical Devices Companies to co-develop innovative orthobiologic solutions for bone graft substitutes and regenerative medicine.

In February 2022, Orthofix Medical Inc. introduced a new synthetic bioactive bone graft solution called Opus B.A., which is used for cervical and lumbar spine fusion procedures.

Products Covered:
• Allograft
• Xenografts
• Synthetic Bone Grafts
• Machined Allografts
• Autografts
• Other Products

Materials Covered:
• Polymers
• Hydroxypaptite
• Beta Tricalcium Phosphate
• Ceramics
• Composites
• Bone Morphogenic Proteins (BMP)
• Demineralized Bone Matrix
• Other Materials

Applications Covered:
• Spinal Fusion
• Craniomaxillofacial
• Foot & Ankle
• Long Bone
• Dental
• Joint Reconstruction
• Trauma & Extremities
• Other Applications

End Users Covered:
• Hospitals
• Specialty Clinics
• Orthopedic Clinics
• Other End Users

Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o UAE
o Qatar
o South Africa
o Rest of Middle East & Africa

What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2021, 2022, 2023, 2026, and 2030
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements

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