Bone Graft Substitutes Market

Bone Graft Substitutes Market Forecasts to 2030 - Global Analysis By Product (Allograft, Xenografts, Synthetic Bone Grafts, Machined Allografts, Autografts and Other Products), Material (Polymers, Hydroxypaptite, Beta Tricalcium Phosphate, Ceramics, Composites, Bone Morphogenic Proteins (BMP), Demineralized Bone Matrix and Other Materials), Application, End User and By Geography

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Published: 2023 ID: SMRC23700

This report covers the impact of COVID-19 on this global market

Years Covered


Estimated Year Value (2023)

US $3.86 BN

Projected Year Value (2030)

US $6.71 BN

CAGR (2023 - 2030)


Regions Covered

North America, Europe, Asia Pacific, South America, and Middle East & Africa

Countries Covered

US, Canada, Mexico, Germany, UK, Italy, France, Spain, Japan, China, India, Australia, New Zealand, South Korea, Rest of Asia Pacific, South America, Argentina, Brazil, Chile, Middle East & Africa, Saudi Arabia, UAE, Qatar, and South Africa

Largest Market

North America

Highest Growing Market

Asia Pacific

According to Stratistics MRC, the Global Bone Graft Substitutes Market is accounted for $3.86 billion in 2023 and is expected to reach $6.71 billion by 2030 growing at a CAGR of 8.2% during the forecast period. Bone grafts substitutes are substances used to fix fractures in the bones or replace missing bones. BGS is often used in surgeries for the hip, foot, and ankle, as well as for fractures and musculoskeletal ailments. The main purposes of employing bone grafts and replacements are to replace natural bone and to assist in the healing of fractures and other bone injuries. Bone graft replacements eliminate the need for extra surgical sites, shorten healing times, and lessen the risk of immunogenicity, disease transmission, and donor-site complications.

According to the Centers for Disease Control and Prevention (CDC) data in January 2021, 1 in 4 adults between 20-64 years of age suffer from at least one cavity, and almost 57% of adolescents aged 12-19 have had a hole in their permanent teeth.

Market Dynamics:


Rise in the geriatric population

The democratization of high-risk sports and the aging of the population have increased the incidence of bone disorders and fractures. With age, the risk of spinal damage rises. Bones become porous and more prone to fractures as we age because bone mineral density diminishes. Bone graft alternatives aid in the quick healing of wounds in the elderly. The rise in occurrences of bone cancer is another factor driving demand for bone grafts and replacements. These factors are accelerating the market's expansion.


Restrictive regulatory environment

The market for alternatives to bone transplants is explicitly regulated and licensed in industrialized countries. Obtaining regulatory clearance for new products may be time-consuming and expensive. The market may be in danger if regulatory procedures change or if approvals take longer than expected. Due to technological limitations on product effectiveness, scalability, and manufacturing techniques, the development of bone graft substitutes may be hindered, which would prohibit the industry from expanding.


Expanding R&D initiatives

Ongoing R&D initiatives to give different product offerings are one of the most well-liked developments in the worldwide industry. This growth in continuing R&D is brought on by the growing need for effective bone graft replacements for bone-related events, such as mild to severe fractures and trauma. There are attempts being conducted all around the world to create new uses for bone grafts in regenerative medicine. The market is also projected to expand as a consequence of several large companies' continued efforts to produce biodegradable polymeric materials and alternatives to bone grafts.


High cost of raw materials

Bone graft substitutes are overpriced, as they are a long-term solution to bone disease treatment. No two patients, or their unique bone transplants and alternative therapies, are precisely same. As a result, there are differences in the number of appointments, processes, and expenses. A difficult poster lateral lumbar spine fusion bone transplant procedure costs thousands of dollars to perform. This element is impeding market expansion.

Covid-19 Impact

With fewer patients in hospitals and speciality clinics owing to the COVID-19 epidemic, replacements have been used less frequently. The pandemic caused major revenue drops for key firms in the bone graft replacements sector. The COVID-19 care-related limits put in place by the government reduced the frequency of patient visits and postponed elective procedures, which had an effect on the sales of these alternatives. In contrast, more people were admitted to hospitals in 2021 as a result of government rules being loosened. Most elective procedures involving the spine and trauma were carried out in hospitals. Such a return to surgical operations in 2021 had a favourable effect on demand for these substitutes.

The ceramic segment is expected to be the largest during the forecast period

The ceramic segment is estimated to have a lucrative growth. Due to its stability and longevity, the ceramic segment is rapidly gaining favour. Bone graft replacements help to maintain space and prevent collapse in load-bearing applications. Because of their porous porosity, ceramics are readily biodegradable and have strong osteoconductivity. The surrounding bone tissues develop and progressively proceed through bone replacement as a result of its introduction in vivo. These several elements support the segment's expansion.

The dental segment is expected to have the highest CAGR during the forecast period

The dental segment is anticipated to witness the fastest CAGR growth during the forecast period, due to the rising prevalence of periodontal and dental disorders including dental caries and dental cavities among the population. Bone graft replacements support strong biting function and stimulation of bone development. One out of every four dental implants requires bone grafting, which is the only way to stop the loss of dental bone. This surgery returns the jaw to its pre-injury state after tooth loss, gum disease, or trauma.

Region with largest share:

North America is projected to hold the largest market share during the forecast period owing to the rising geriatric population and increasing incidence of sports injuries & fatal accidents. In the region, the prevalence of joint-related illnesses such osteoarthritis, rheumatoid arthritis, and arthritis is on the rise. The acceptance of such items is also being aided by the region's well-established healthcare infrastructure, favourable reimbursement rules, and plenty of orthopedic surgeons who conduct operations involving bone transplants.

Region with highest CAGR:

Asia Pacific is projected to have the highest CAGR over the forecast period, owing to the surge in medical tourism and beneficial government policies. This region has huge geriatric population. With an increase in the geriatric population, there is a rise in the number of people suffering from various arthritis problems which increases the demand for bone grafting procedures. Furthermore, the presence of a larger patient pool with a range of orthopedic conditions, and rising investments by market participants to expand their presence in the region are expected to drive the market in Asia Pacific region.

Key players in the market

Some of the key players in Bone Graft Substitutes Market include AlloSource, Arthrex, Inc., Aziyo Biologics, Inc., Baxter International Inc., Bioventus LLC, Coloplast Corp., Integra LifeSciences Corporation, Johnson & Johnson, LifeNet Health, Medtronic, NuVasive, Inc., Olympus Corporation, Orthofix Medical Inc.,RTI Surgical Holdings, Inc., SeaSpine Holdings Corporation, Stryker Corporation, Wright Medical Group N.V., Xtant Medical, Holdings, Inc., Zimmer Biomet Holdings, Inc. and TBF Tissue Engineering.

Key Developments:

In May 2023, Zimmer Biomet Holdings, Inc. announced the launch of its VIVIX 3D Printed Bone Matrix, a breakthrough bone graft substitute with a porous structure designed to mimic the natural bone environment.

In April 2023, Stryker Corporation acquired NuVasive, Inc., a leading provider of spine surgery solutions, expanding its product portfolio in the bone graft substitutes market and strengthening its presence in the spine care segment.

In December 2022, Kuros Biosciences announced a collaboration with Johnson & Johnson Medical Devices Companies to co-develop innovative orthobiologic solutions for bone graft substitutes and regenerative medicine.

In February 2022, Orthofix Medical Inc. introduced a new synthetic bioactive bone graft solution called Opus B.A., which is used for cervical and lumbar spine fusion procedures.

Products Covered:
• Allograft
• Xenografts
• Synthetic Bone Grafts
• Machined Allografts
• Autografts
• Other Products

Materials Covered:
• Polymers
• Hydroxypaptite
• Beta Tricalcium Phosphate
• Ceramics
• Composites
• Bone Morphogenic Proteins (BMP)
• Demineralized Bone Matrix
• Other Materials

Applications Covered:
• Spinal Fusion
• Craniomaxillofacial
• Foot & Ankle
• Long Bone
• Dental
• Joint Reconstruction
• Trauma & Extremities
• Other Applications

End Users Covered:
• Hospitals
• Specialty Clinics
• Orthopedic Clinics
• Other End Users

Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o Qatar
o South Africa
o Rest of Middle East & Africa

What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2021, 2022, 2023, 2026, and 2030
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements

Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
o Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances

Table of Contents

1 Executive Summary

2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions

3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 Application Analysis
3.8 End User Analysis
3.9 Emerging Markets
3.10 Impact of Covid-19

4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry

5 Global Bone Graft Substitutes Market, By Product
5.1 Introduction
5.2 Allograft
5.3 Xenografts
5.4 Synthetic Bone Grafts
5.5 Machined Allografts
5.6 Autografts
5.7 Other Products

6 Global Bone Graft Substitutes Market, By Material
6.1 Introduction
6.2 Polymers
6.3 Hydroxypaptite
6.4 Beta Tricalcium Phosphate
6.5 Ceramics
6.6 Composites
6.7 Bone Morphogenic Proteins (BMP)
6.8 Demineralized Bone Matrix
6.9 Other Materials

7 Global Bone Graft Substitutes Market, By Application
7.1 Introduction
7.2 Spinal Fusion
7.3 Craniomaxillofacial
7.4 Foot & Ankle
7.5 Long Bone
7.6 Dental
7.7 Joint Reconstruction
7.8 Trauma & Extremities
7.9 Other Applications

8 Global Bone Graft Substitutes Market, By End User
8.1 Introduction
8.2 Hospitals
8.3 Specialty Clinics
8.4 Orthopedic Clinics
8.5 Other End Users

9 Global Bone Graft Substitutes Market, By Geography
9.1 Introduction
9.2 North America
9.2.1 US
9.2.2 Canada
9.2.3 Mexico
9.3 Europe
9.3.1 Germany
9.3.2 UK
9.3.3 Italy
9.3.4 France
9.3.5 Spain
9.3.6 Rest of Europe
9.4 Asia Pacific
9.4.1 Japan
9.4.2 China
9.4.3 India
9.4.4 Australia
9.4.5 New Zealand
9.4.6 South Korea
9.4.7 Rest of Asia Pacific
9.5 South America
9.5.1 Argentina
9.5.2 Brazil
9.5.3 Chile
9.5.4 Rest of South America
9.6 Middle East & Africa
9.6.1 Saudi Arabia
9.6.2 UAE
9.6.3 Qatar
9.6.4 South Africa
9.6.5 Rest of Middle East & Africa

10 Key Developments
10.1 Agreements, Partnerships, Collaborations and Joint Ventures
10.2 Acquisitions & Mergers
10.3 New Product Launch
10.4 Expansions
10.5 Other Key Strategies

11 Company Profiling
11.1 AlloSource
11.2 Arthrex, Inc.
11.3 Aziyo Biologics, Inc.
11.4 Baxter International Inc.
11.5 Bioventus LLC
11.6 Coloplast Corp.
11.7 Integra LifeSciences Corporation
11.8 Johnson & Johnson
11.9 LifeNet Health
11.10 Medtronic
11.11 NuVasive, Inc.
11.12 Olympus Corporation
11.13 Orthofix Medical Inc.
11.14 RTI Surgical Holdings, Inc.
11.15 SeaSpine Holdings Corporation
11.16 Stryker Corporation
11.17 Wright Medical Group N.V.
11.18 Xtant Medical Holdings, Inc.
11.19 Zimmer Biomet Holdings, Inc.
11.20 TBF Tissue Engineering

List of Tables
1 Global Bone Graft Substitutes Market Outlook, By Region (2021-2030) ($MN)
2 Global Bone Graft Substitutes Market Outlook, By Product (2021-2030) ($MN)
3 Global Bone Graft Substitutes Market Outlook, By Allograft (2021-2030) ($MN)
4 Global Bone Graft Substitutes Market Outlook, By Xenografts (2021-2030) ($MN)
5 Global Bone Graft Substitutes Market Outlook, By Synthetic Bone Grafts (2021-2030) ($MN)
6 Global Bone Graft Substitutes Market Outlook, By Machined Allografts (2021-2030) ($MN)
7 Global Bone Graft Substitutes Market Outlook, By Autografts (2021-2030) ($MN)
8 Global Bone Graft Substitutes Market Outlook, By Other Products (2021-2030) ($MN)
9 Global Bone Graft Substitutes Market Outlook, By Material (2021-2030) ($MN)
10 Global Bone Graft Substitutes Market Outlook, By Polymers (2021-2030) ($MN)
11 Global Bone Graft Substitutes Market Outlook, By Hydroxypaptite (2021-2030) ($MN)
12 Global Bone Graft Substitutes Market Outlook, By Beta Tricalcium Phosphate (2021-2030) ($MN)
13 Global Bone Graft Substitutes Market Outlook, By Ceramics (2021-2030) ($MN)
14 Global Bone Graft Substitutes Market Outlook, By Composites (2021-2030) ($MN)
15 Global Bone Graft Substitutes Market Outlook, By Bone Morphogenic Proteins (BMP) (2021-2030) ($MN)
16 Global Bone Graft Substitutes Market Outlook, By Demineralized Bone Matrix (2021-2030) ($MN)
17 Global Bone Graft Substitutes Market Outlook, By Other Materials (2021-2030) ($MN)
18 Global Bone Graft Substitutes Market Outlook, By Application (2021-2030) ($MN)
19 Global Bone Graft Substitutes Market Outlook, By Spinal Fusion (2021-2030) ($MN)
20 Global Bone Graft Substitutes Market Outlook, By Craniomaxillofacial (2021-2030) ($MN)
21 Global Bone Graft Substitutes Market Outlook, By Foot & Ankle (2021-2030) ($MN)
22 Global Bone Graft Substitutes Market Outlook, By Long Bone (2021-2030) ($MN)
23 Global Bone Graft Substitutes Market Outlook, By Dental (2021-2030) ($MN)
24 Global Bone Graft Substitutes Market Outlook, By Joint Reconstruction (2021-2030) ($MN)
25 Global Bone Graft Substitutes Market Outlook, By Trauma & Extremities (2021-2030) ($MN)
26 Global Bone Graft Substitutes Market Outlook, By Other Applications (2021-2030) ($MN)
27 Global Bone Graft Substitutes Market Outlook, By End User (2021-2030) ($MN)
28 Global Bone Graft Substitutes Market Outlook, By Hospitals (2021-2030) ($MN)
29 Global Bone Graft Substitutes Market Outlook, By Specialty Clinics (2021-2030) ($MN)
30 Global Bone Graft Substitutes Market Outlook, By Orthopedic Clinics (2021-2030) ($MN)
31 Global Bone Graft Substitutes Market Outlook, By Other End Users (2021-2030) ($MN)

Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.

List of Figures


Research Methodology

We at Stratistics opt for an extensive research approach which involves data mining, data validation, and data analysis. The various research sources include in-house repository, secondary research, competitor’s sources, social media research, client internal data, and primary research.

Our team of analysts prefers the most reliable and authenticated data sources in order to perform the comprehensive literature search. With access to most of the authenticated data bases our team highly considers the best mix of information through various sources to obtain extensive and accurate analysis.

Each report takes an average time of a month and a team of 4 industry analysts. The time may vary depending on the scope and data availability of the desired market report. The various parameters used in the market assessment are standardized in order to enhance the data accuracy.

Data Mining

The data is collected from several authenticated, reliable, paid and unpaid sources and is filtered depending on the scope & objective of the research. Our reports repository acts as an added advantage in this procedure. Data gathering from the raw material suppliers, distributors and the manufacturers is performed on a regular basis, this helps in the comprehensive understanding of the products value chain. Apart from the above mentioned sources the data is also collected from the industry consultants to ensure the objective of the study is in the right direction.

Market trends such as technological advancements, regulatory affairs, market dynamics (Drivers, Restraints, Opportunities and Challenges) are obtained from scientific journals, market related national & international associations and organizations.

Data Analysis

From the data that is collected depending on the scope & objective of the research the data is subjected for the analysis. The critical steps that we follow for the data analysis include:

  • Product Lifecycle Analysis
  • Competitor analysis
  • Risk analysis
  • Porters Analysis
  • PESTEL Analysis
  • SWOT Analysis

The data engineering is performed by the core industry experts considering both the Marketing Mix Modeling and the Demand Forecasting. The marketing mix modeling makes use of multiple-regression techniques to predict the optimal mix of marketing variables. Regression factor is based on a number of variables and how they relate to an outcome such as sales or profits.

Data Validation

The data validation is performed by the exhaustive primary research from the expert interviews. This includes telephonic interviews, focus groups, face to face interviews, and questionnaires to validate our research from all aspects. The industry experts we approach come from the leading firms, involved in the supply chain ranging from the suppliers, distributors to the manufacturers and consumers so as to ensure an unbiased analysis.

We are in touch with more than 15,000 industry experts with the right mix of consultants, CEO's, presidents, vice presidents, managers, experts from both supply side and demand side, executives and so on.

The data validation involves the primary research from the industry experts belonging to:

  • Leading Companies
  • Suppliers & Distributors
  • Manufacturers
  • Consumers
  • Industry/Strategic Consultants

Apart from the data validation the primary research also helps in performing the fill gap research, i.e. providing solutions for the unmet needs of the research which helps in enhancing the reports quality.

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