Proteins are the largest and most important biomolecules in a living organism, as they are vital to the functioning of an organism. Once they are formed within a cell, proteins interact with other biomolecules and carry out roles to keep the cell alive. Therefore, more importance is given to research the protein binding mechanism through specialized fields of studies, such as proteomics and protein chemistry. Most of these techniques focus on the ability to specifically tag proteins by creating genetic fusions, and thereby, imparting distinctive properties for selective protein visualization, manipulation, and entrapment within complex biochemical environments. Diverse strategies are used to carry out successful protein labeling. Protein labeling is an effective technique to study protein structure, function, and functioning of genes. This technique is a secondary research tool for proteomic analysis, and is used for research and diagnostic purposes in biotechnology and pharmaceuticals industries. It is carried out using labeling reagents and kits to label an antibody or other protein, to make a fluorescent probe, enzyme conjugate, biotinylated binding reagent, or iodine-labeled tracer for detecting proteins in tissues, cells, and biochemical assays.
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Protein labeling comprises different labels depending on different uses for a certain definite application. This labeling is widely implemented in most immunological techniques such as flow cytometry, immunoassays, and immunofluorescence. These immunological assays are highly adopted in therapeutics, cancer research, autoimmune diseases, and endocrine diseases such as diabetes, rheumatoid arthritis, and pulmonary diseases. The main applications for protein labeling are biological processes monitoring, reliable quantification of compounds and specific detection of protein modifications and isoforms in multiplexed samples, enhancement of detection sensitivity and simplification of detection workflows.
The “Global Protein Labeling Market” is expected to grow from $1,133.48 million in 2016 to reach $2030.65 million by 2022 with a CAGR of 10.2%.
The protein labeling market is anticipated to fortify its demand on a global platform with the advancement in proteomics research. Market growth opportunities are likely to arise from the increasing usage of protein labeling in various labeling methodologies such as bioorthogonal, in vivo, and in vitro. Other major reasons answerable for the tangible growth in the global market could be the elevating research and development and healthcare expenditure. The chief uses of protein labeling include the examination of biological processes, managing multiplexed samples with the help of protein modifications, and precise quantification and identification of isomers. Before the analysis and separation of amino acids or proteins, it is recommended to consider as an essentiality for proteomic profiling. Moreover, development in the technology to fabricate advanced dyes that quickly conjugates with the specific peptides or nucleotidein order to detect their presence and further purification process more accurately are expected to make the process more efficient and will have positive impact on the market.
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Improvements in accuracy, resolution and procedures used in techniques such as fluorescence & biorthogonal tagging are estimated to grow over the forecast period. In addition, smaller companies enter the market with customized protein labeling kits, while the larger companies have focused on new product launch to customize according to the researchers’ requirements. Technological advancements in genetic sequencing methodologies have drastically reduced the cost of genome profiling. This is likely to drive demand for protein expression analysis, which is the next step in genetic analysis after sequencing. Advanced protein labeling methods offer better and improved opportunities for their use in varied applications.
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Protein labeling market in North America is anticipated to have significant growth during the forecast period, due to various technological advancements, rise in R&D investments, surge in demand for protein labeling products and the presence of major protein labelling market players in the region. Key protein labelling market players are continuously engaged in enhancing their portfolios. Rise in the adoption rate of this technique owing to the development of genomic sequencing and personalized medicine in North America is propelling the protein labelling market. The North American countries of the United States (US) and Canada have a developed and well-structured health care system. These systems also encourage research and development. This region generates highest revenues across the globe owing to continuing projects on gene expression control, protein-protein interaction, and in-vivo quantitative proteomics. In addition, Canada is leading the lucrative growth owing to the growing number of research projects focused on improving healthcare solutions. Moreover, Protein labeling research has achieved a boost in North America owing to the funding support provided by the government. For instance, in 2012, a scientist from Scripps Research Institute in California, U.S., received a grant of $1.5 million from the National Institutes of Health (NIH) to develop a new method for targeting RNA in genome. This new computer-based design method is anticipated to enable targeting the RNA in the human genome to discover new therapeutics.