Herg Screening Market
HERG Screening Market Forecasts to 2028 - Global Analysis By Type (Gene KCNH2, Mutant KCNH2 and Other Types), Ion Channel (Voltage Gated, Ligand Gated and Other Ion Channels), Application (Antiarrhythmic, Antipsychotic, Antibiotics and Other Applications) and By Geography
|
Years Covered |
2020-2028 |
|
Estimated Year Value (2022) |
US $1942.10 MN |
|
Projected Year Value (2028) |
US $4756.25 MN |
|
CAGR (2022 - 2028) |
16.10% |
|
Regions Covered |
North America, Europe, Asia Pacific, South America, and Middle East & Africa |
|
Countries Covered |
US, Canada, Mexico, Germany, UK, Italy, France, Spain, Japan, China, India, Australia, New Zealand, South Korea, Rest of Asia Pacific, South America, Argentina, Brazil, Chile, Middle East & Africa, Saudi Arabia, UAE, Qatar, and South Africa |
|
Largest Market |
North America |
|
Highest Growing Market |
Asia Pacific |
According to Stratistics MRC, the Global HERG Screening Market is accounted for $1,942.10 million in 2022 and is expected to reach $4,756.25 million by 2028 growing at a CAGR of 16.10% during the forecast period. The human Ether-a-go-go-Related Gene, also known as HERG, is a gene that produces the Kvll protein. 1 the potassium ion channel's alpha subunit. By giving the cardiac action potential a repolarizing current, its channels assist in controlling the heartbeat. The HERG evaluations are now before the submission of the investigational new drug, this was one of the prerequisites set by the regulatory agencies. Some HERG screening assays resemble patch clamp assays that are either manual or automatic. Microelectrode array, fluorescence polarization analysis and HERG radioligand binding test. Auto-patching clamp check the HERG current at different concentrations.
According to the annual report published by the Center for Drug Evaluation and Research (CDER), an estimated 25 drugs received novel drugs approval for marketing in 2016, whereas 59 in 2018.
Market Dynamics:
Driver:
Increase in heart disease prevalence
In the entire world, heart disease is the leading cause of death for both men and women. An American will have a myocardial infarction every 40 seconds, according to the American College of Cardiology. The article continued by noting that emergency medical services estimated that 356,461 Americans had gone into cardiac arrest outside of a hospital in 2017, and emergency medical services treatment had begun in 52% of those cases. Only 18.7% of the patients initially had a heart rhythm that could be shockable by an AED, such as ventricular fibrillation or ventricular tachycardia. Adults had an overall survival rate of 10.4% and an 8.4% good functional status.
Restraint:
Expensive herg screening products
The global HERG Screening market expected to hinder growth during the forecast period. The cost of the vial used in HERG screening is high as a result of the market's poor growth. Utilizing modern technology has resulted in an increase in the price of the products used in the screening process. For USD 879 per vial, the Eurofins DiscoverX Corporation offers a precision recombinant HERG potassium ion channel membrane preparation. These factors are expected to restrict market growth.
Opportunity:
Unexploited markets
Companies that manufacture products or partner with smaller companies operating in new markets as distributors additionally, markets in China, India, Brazil, Russia, and South Africa remain untapped. In these nations, heart disease is also becoming more prevalent. A study that was released in 2016 found that there were 23.8 million people in India who had ischemic heart disease. 1,6.5 million stroke cases were reported in India in 2016. The increased prevalence of these untapped markets means that businesses have a lot of room to grow.
Threat:
Drug toxicity of herg
The global HERG Screening market expected to hamper growth during the forecast period. The human ether-a-go-go-related gene (hERG) potassium ion channel is frequently unintentionally blocked by drug candidates. Long QT syndrome (LQTS), a serious, life-threatening cardiac side effect, is caused by the blockage. Therefore, by eliminating toxic drug candidates, a virtual screening method to predict drug-induced hERG-related cardiotoxicity could speed up drug discovery. One of the adverse effects and a significant contributor to drug withdrawals during drug discovery is cardiac toxicity.
Covid-19 Impact:
In the early stages of the COVID-19 pandemic, there were no specialized diagnostic tests available to identify the illness in patients. Initially, alternative diagnostic procedures were used, but they weren't very successful. Due to the unavailability of certain COVID-19 diagnostic tests, diagnostic manufacturers had lucrative opportunities to release COVID-19 diagnostic kits. Utilizing this chance, a number of established companies as well as a few start-ups from different nations introduced COVID-19 diagnostic kits into the local as well as international markets.
The voltage gated segment is expected to be the largest during the forecast period
During the forecasted period, voltage-gated ion channels held the largest share in the hERG market. Screening for the human ether-a-go-go-related gene (hERG) in the early stages of drug discovery and development, robust growth in pharmaceutical companies for hERG screening of lead compounds, and difficulties in developing products useful for pharmaceutical and biotechnology applications are the main factors attributed to the market growth of this segment.
The gene kcnh2 segment is expected to have the highest CAGR during the forecast period
The Gene KCNH2 segment is anticipated to grow at a rate of 15.20% over the course of the forecast period. This channel is particularly important for both the generation and transmission of electrical impulses because it is in charge of removing positively charged potassium atoms from the cells. This is because it is in charge of moving the atoms of potassium. The synthesis of potassium channels is regulated by the KCNH2 gene, which also provides the necessary instructions for doing so. The eventual emergence of cardiac arrhythmias is primarily caused by the KCNH2 mutation. Similar to the KCNH2 gene, a mutation or KCNH2 deficiency can result in prolonged QT syndrome. Prolonged QT syndrome is thought to affect one in 5,000 to one in 10,000 individuals worldwide, according to estimates.
Region with largest share:
The North America region market is estimated to witness a largest share of the global HERG Screening market during the forecast period. An American citizen will experience a myocardial infarction every 40 seconds, according to the study of the American College of Cardiology. 356,460 Americans went through an out-of-hospital cardiac arrest in 2017, and emergency medical services were called in for 52% of those cases, the report claims. Only 18.75% of the initially reported cardiac rhythms were ventricular fibrillation, ventricular tachycardia, or shockable by an AED. 8.4% of adults who were hospitalized survived to be released, and 10.4% of them had good functional status.
Region with highest CAGR:
Asia Pacific is projected to have the highest CAGR over the forecast period. During the forecast period, Asia-Pacific is anticipated to have the highest CAGR. This region has more new product launches, which will increase the amount of R&D in the herg screening market. Additionally, the Asia-Pacific region receives more approvals for new drugs, which will spur market expansion. In this region, there will likely be an increase in demand for drug formulation and development to treat illnesses and disorders as a result of the rising number of approvals.
Key players in the market
Some of the key players in HERG Screening market include A PerkinElmer Company, Abcam PLC, ABR-Affinity BioReagents, Inc., AstraZeneca Plc, Aureus Sciences, Aurora Biomed Inc., AVIVA Biosciences, B'SYS GmbH, Cambridge Bioscience Ltd, Cellular Dynamics International, ChanTest Corporation, Charles River Laboratories Inc., ChemAxon, Creative bioarray, Cyprotex Limited, Eurofins-Cerep SA., Merck KGaA, Metrion biosciences and Molecular Devices LLC.
Key Developments:
In March 2020, Charles River Laboratories entered a partnership with Deciphex, a leader in preclinical digital pathology software-as-a-service. In addition to Charles River being the exclusive contract research organization distributing the Patholytix preclinical solution to clients, the organizations will work together to co-develop deep learning-enabled tools to support accelerated pathology analytics.
In July 2017, Eurofins Scientific announced the acquisition of Discover X, a leader in drug discovery products and services across all stages of discovery from target identification and lead discovery to preclinical and beyond.
Types Covered:
• Gene KCNH2
• Mutant KCNH2
• Other Types
Ion Channels Covered:
• Voltage Gated
• Ligand Gated
• Other Ion Channels
Applications Covered:
• Antiarrhythmic
• Antipsychotic
• Antibiotics
• Other Applications
Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o UAE
o Qatar
o South Africa
o Rest of Middle East & Africa
What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2020, 2021, 2022, 2025, and 2028
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements
Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances
Table of Contents
1 Executive Summary
2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions
3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Application Analysis
3.7 Emerging Markets
3.8 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global HERG Screening Market, By Type
5.1 Introduction
5.2 Gene KCNH2
5.3 Mutant KCNH2
5.4 Other Types
6 Global HERG Screening Market, By Ion Channel
6.1 Introduction
6.2 Voltage Gated
6.3 Ligand Gated
6.4 Other Ion Channels
7 Global HERG Screening Market, By Application
7.1 Introduction
7.2 Antiarrhythmic
7.3 Antipsychotic
7.4 Antibiotics
7.5 Other Applications
8 Global HERG Screening Market, By Geography
8.1 Introduction
8.2 North America
8.2.1 US
8.2.2 Canada
8.2.3 Mexico
8.3 Europe
8.3.1 Germany
8.3.2 UK
8.3.3 Italy
8.3.4 France
8.3.5 Spain
8.3.6 Rest of Europe
8.4 Asia Pacific
8.4.1 Japan
8.4.2 China
8.4.3 India
8.4.4 Australia
8.4.5 New Zealand
8.4.6 South Korea
8.4.7 Rest of Asia Pacific
8.5 South America
8.5.1 Argentina
8.5.2 Brazil
8.5.3 Chile
8.5.4 Rest of South America
8.6 Middle East & Africa
8.6.1 Saudi Arabia
8.6.2 UAE
8.6.3 Qatar
8.6.4 South Africa
8.6.5 Rest of Middle East & Africa
9 Key Developments
9.1 Agreements, Partnerships, Collaborations and Joint Ventures
9.2 Acquisitions & Mergers
9.3 New Product Launch
9.4 Expansions
9.5 Other Key Strategies
10 Company Profiling
10.1 A PerkinElmer Company
10.2 Abcam PLC
10.3 ABR-Affinity BioReagents, Inc.
10.4 AstraZeneca Plc
10.5 Aureus Sciences
10.6 Aurora Biomed Inc.
10.7 AVIVA Biosciences
10.8 B'SYS GmbH
10.9 Cambridge Bioscience Ltd
10.10 Cellular Dynamics International
10.11 ChanTest Corporation
10.12 Charles River Laboratories Inc.
10.13 ChemAxon
10.14 Creative bioarray
10.15 Cyprotex Limited
10.16 Eurofins-Cerep SA.
10.17 Merck KGaA
10.18 Metrion biosciences
10.19 Molecular Devices LLC
List of Tables
1 Global HERG Screening Market Outlook, By Region (2020-2028) ($MN)
2 Global HERG Screening Market Outlook, By Type (2020-2028) ($MN)
3 Global HERG Screening Market Outlook, By Gene KCNH2 (2020-2028) ($MN)
4 Global HERG Screening Market Outlook, By Mutant KCNH2 (2020-2028) ($MN)
5 Global HERG Screening Market Outlook, By Other Types (2020-2028) ($MN)
6 Global HERG Screening Market Outlook, By Ion Channel (2020-2028) ($MN)
7 Global HERG Screening Market Outlook, By Voltage Gated (2020-2028) ($MN)
8 Global HERG Screening Market Outlook, By Ligand Gated (2020-2028) ($MN)
9 Global HERG Screening Market Outlook, By Other Ion Channels (2020-2028) ($MN)
10 Global HERG Screening Market Outlook, By Application (2020-2028) ($MN)
11 Global HERG Screening Market Outlook, By Antiarrhythmic (2020-2028) ($MN)
12 Global HERG Screening Market Outlook, By Antipsychotic (2020-2028) ($MN)
13 Global HERG Screening Market Outlook, By Antibiotics (2020-2028) ($MN)
14 Global HERG Screening Market Outlook, By Other Applications (2020-2028) ($MN)
15 North America HERG Screening Market Outlook, By Country (2020-2028) ($MN)
16 North America HERG Screening Market Outlook, By Type (2020-2028) ($MN)
17 North America HERG Screening Market Outlook, By Gene KCNH2 (2020-2028) ($MN)
18 North America HERG Screening Market Outlook, By Mutant KCNH2 (2020-2028) ($MN)
19 North America HERG Screening Market Outlook, By Other Types (2020-2028) ($MN)
20 North America HERG Screening Market Outlook, By Ion Channel (2020-2028) ($MN)
21 North America HERG Screening Market Outlook, By Voltage Gated (2020-2028) ($MN)
22 North America HERG Screening Market Outlook, By Ligand Gated (2020-2028) ($MN)
23 North America HERG Screening Market Outlook, By Other Ion Channels (2020-2028) ($MN)
24 North America HERG Screening Market Outlook, By Application (2020-2028) ($MN)
25 North America HERG Screening Market Outlook, By Antiarrhythmic (2020-2028) ($MN)
26 North America HERG Screening Market Outlook, By Antipsychotic (2020-2028) ($MN)
27 North America HERG Screening Market Outlook, By Antibiotics (2020-2028) ($MN)
28 North America HERG Screening Market Outlook, By Other Applications (2020-2028) ($MN)
29 Europe HERG Screening Market Outlook, By Country (2020-2028) ($MN)
30 Europe HERG Screening Market Outlook, By Type (2020-2028) ($MN)
31 Europe HERG Screening Market Outlook, By Gene KCNH2 (2020-2028) ($MN)
32 Europe HERG Screening Market Outlook, By Mutant KCNH2 (2020-2028) ($MN)
33 Europe HERG Screening Market Outlook, By Other Types (2020-2028) ($MN)
34 Europe HERG Screening Market Outlook, By Ion Channel (2020-2028) ($MN)
35 Europe HERG Screening Market Outlook, By Voltage Gated (2020-2028) ($MN)
36 Europe HERG Screening Market Outlook, By Ligand Gated (2020-2028) ($MN)
37 Europe HERG Screening Market Outlook, By Other Ion Channels (2020-2028) ($MN)
38 Europe HERG Screening Market Outlook, By Application (2020-2028) ($MN)
39 Europe HERG Screening Market Outlook, By Antiarrhythmic (2020-2028) ($MN)
40 Europe HERG Screening Market Outlook, By Antipsychotic (2020-2028) ($MN)
41 Europe HERG Screening Market Outlook, By Antibiotics (2020-2028) ($MN)
42 Europe HERG Screening Market Outlook, By Other Applications (2020-2028) ($MN)
43 Asia Pacific HERG Screening Market Outlook, By Country (2020-2028) ($MN)
44 Asia Pacific HERG Screening Market Outlook, By Type (2020-2028) ($MN)
45 Asia Pacific HERG Screening Market Outlook, By Gene KCNH2 (2020-2028) ($MN)
46 Asia Pacific HERG Screening Market Outlook, By Mutant KCNH2 (2020-2028) ($MN)
47 Asia Pacific HERG Screening Market Outlook, By Other Types (2020-2028) ($MN)
48 Asia Pacific HERG Screening Market Outlook, By Ion Channel (2020-2028) ($MN)
49 Asia Pacific HERG Screening Market Outlook, By Voltage Gated (2020-2028) ($MN)
50 Asia Pacific HERG Screening Market Outlook, By Ligand Gated (2020-2028) ($MN)
51 Asia Pacific HERG Screening Market Outlook, By Other Ion Channels (2020-2028) ($MN)
52 Asia Pacific HERG Screening Market Outlook, By Application (2020-2028) ($MN)
53 Asia Pacific HERG Screening Market Outlook, By Antiarrhythmic (2020-2028) ($MN)
54 Asia Pacific HERG Screening Market Outlook, By Antipsychotic (2020-2028) ($MN)
55 Asia Pacific HERG Screening Market Outlook, By Antibiotics (2020-2028) ($MN)
56 Asia Pacific HERG Screening Market Outlook, By Other Applications (2020-2028) ($MN)
57 South America HERG Screening Market Outlook, By Country (2020-2028) ($MN)
58 South America HERG Screening Market Outlook, By Type (2020-2028) ($MN)
59 South America HERG Screening Market Outlook, By Gene KCNH2 (2020-2028) ($MN)
60 South America HERG Screening Market Outlook, By Mutant KCNH2 (2020-2028) ($MN)
61 South America HERG Screening Market Outlook, By Other Types (2020-2028) ($MN)
62 South America HERG Screening Market Outlook, By Ion Channel (2020-2028) ($MN)
63 South America HERG Screening Market Outlook, By Voltage Gated (2020-2028) ($MN)
64 South America HERG Screening Market Outlook, By Ligand Gated (2020-2028) ($MN)
65 South America HERG Screening Market Outlook, By Other Ion Channels (2020-2028) ($MN)
66 South America HERG Screening Market Outlook, By Application (2020-2028) ($MN)
67 South America HERG Screening Market Outlook, By Antiarrhythmic (2020-2028) ($MN)
68 South America HERG Screening Market Outlook, By Antipsychotic (2020-2028) ($MN)
69 South America HERG Screening Market Outlook, By Antibiotics (2020-2028) ($MN)
70 South America HERG Screening Market Outlook, By Other Applications (2020-2028) ($MN)
71 Middle East & Africa HERG Screening Market Outlook, By Country (2020-2028) ($MN)
72 Middle East & Africa HERG Screening Market Outlook, By Type (2020-2028) ($MN)
73 Middle East & Africa HERG Screening Market Outlook, By Gene KCNH2 (2020-2028) ($MN)
74 Middle East & Africa HERG Screening Market Outlook, By Mutant KCNH2 (2020-2028) ($MN)
75 Middle East & Africa HERG Screening Market Outlook, By Other Types (2020-2028) ($MN)
76 Middle East & Africa HERG Screening Market Outlook, By Ion Channel (2020-2028) ($MN)
77 Middle East & Africa HERG Screening Market Outlook, By Voltage Gated (2020-2028) ($MN)
78 Middle East & Africa HERG Screening Market Outlook, By Ligand Gated (2020-2028) ($MN)
79 Middle East & Africa HERG Screening Market Outlook, By Other Ion Channels (2020-2028) ($MN)
80 Middle East & Africa HERG Screening Market Outlook, By Application (2020-2028) ($MN)
81 Middle East & Africa HERG Screening Market Outlook, By Antiarrhythmic (2020-2028) ($MN)
82 Middle East & Africa HERG Screening Market Outlook, By Antipsychotic (2020-2028) ($MN)
83 Middle East & Africa HERG Screening Market Outlook, By Antibiotics (2020-2028) ($MN)
84 Middle East & Africa HERG Screening Market Outlook, By Other Applications (2020-2028) ($MN)
List of Figures
RESEARCH METHODOLOGY
We at ‘Stratistics’ opt for an extensive research approach which involves data mining, data validation, and data analysis. The various research sources include in-house repository, secondary research, competitor’s sources, social media research, client internal data, and primary research.
Our team of analysts prefers the most reliable and authenticated data sources in order to perform the comprehensive literature search. With access to most of the authenticated data bases our team highly considers the best mix of information through various sources to obtain extensive and accurate analysis.
Each report takes an average time of a month and a team of 4 industry analysts. The time may vary depending on the scope and data availability of the desired market report. The various parameters used in the market assessment are standardized in order to enhance the data accuracy.
Data Mining
The data is collected from several authenticated, reliable, paid and unpaid sources and is filtered depending on the scope & objective of the research. Our reports repository acts as an added advantage in this procedure. Data gathering from the raw material suppliers, distributors and the manufacturers is performed on a regular basis, this helps in the comprehensive understanding of the products value chain. Apart from the above mentioned sources the data is also collected from the industry consultants to ensure the objective of the study is in the right direction.
Market trends such as technological advancements, regulatory affairs, market dynamics (Drivers, Restraints, Opportunities and Challenges) are obtained from scientific journals, market related national & international associations and organizations.
Data Analysis
From the data that is collected depending on the scope & objective of the research the data is subjected for the analysis. The critical steps that we follow for the data analysis include:
- Product Lifecycle Analysis
- Competitor analysis
- Risk analysis
- Porters Analysis
- PESTEL Analysis
- SWOT Analysis
The data engineering is performed by the core industry experts considering both the Marketing Mix Modeling and the Demand Forecasting. The marketing mix modeling makes use of multiple-regression techniques to predict the optimal mix of marketing variables. Regression factor is based on a number of variables and how they relate to an outcome such as sales or profits.
Data Validation
The data validation is performed by the exhaustive primary research from the expert interviews. This includes telephonic interviews, focus groups, face to face interviews, and questionnaires to validate our research from all aspects. The industry experts we approach come from the leading firms, involved in the supply chain ranging from the suppliers, distributors to the manufacturers and consumers so as to ensure an unbiased analysis.
We are in touch with more than 15,000 industry experts with the right mix of consultants, CEO's, presidents, vice presidents, managers, experts from both supply side and demand side, executives and so on.
The data validation involves the primary research from the industry experts belonging to:
- Leading Companies
- Suppliers & Distributors
- Manufacturers
- Consumers
- Industry/Strategic Consultants
Apart from the data validation the primary research also helps in performing the fill gap research, i.e. providing solutions for the unmet needs of the research which helps in enhancing the reports quality.
For more details about research methodology, kindly write to us at info@strategymrc.com
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