In Vivo Toxicology Market

In Vivo Toxicology Market

In Vivo Toxicology Market Forecasts to 2028 - Global Analysis By Product (Consumables, Instruments and Other Products), Testing Facility (Outsourced Testing Facility and In-House Testing Facility), Test Type (Sub-Acute, Acute, Sub-Chronic, Chronic and Other Test Types), Toxicity End Point, End User and By Geography

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Published: 2023 ID: SMRC22814

This report covers the impact of COVID-19 on this global market

Years Covered


Estimated Year Value (2022)

US $5.56 BN

Projected Year Value (2028)

US $7.67 BN

CAGR (2022 - 2028)


Regions Covered

North America, Europe, Asia Pacific, South America, and Middle East & Africa

Countries Covered

US, Canada, Mexico, Germany, UK, Italy, France, Spain, Japan, China, India, Australia, New Zealand, South Korea, Rest of Asia Pacific, South America, Argentina, Brazil, Chile, Middle East & Africa, Saudi Arabia, UAE, Qatar, and South Africa

Largest Market

North America

Highest Growing Market


According to Stratistics MRC, the Global In Vivo Toxicology Market is accounted for $5.56 billion in 2022 and is expected to reach $7.67 billion by 2028 growing at a CAGR of 5.5% during the forecast period. Vivo toxicology is the study of the toxicity of various medications on a living organism, usually an animal. This is in contrast to in vitro toxicology, which uses non-living technologies like as computer models and cell lines. This type of testing investigates how chemicals and medications affect the behaviour and health of living animals. This data is used in the creation of critical drugs that can help prevent and treat specific human diseases such as cancer and Alzheimer's.

According to the Centers for Disease Control and Prevention (CDC), in 2021, around 18.2 million adults aged 20 and older had coronary artery disease (CAD) in the United States. Heart disease is the leading cause of death among people in the United States.

Market Dynamics:


Unique In vivo toxicological tests

Several toxicological tests are now carried out in laboratories, thanks to the emergence of alternative methodologies such as in vitro and in silico toxicity testing. Certain assays, however, are only available in vivo, such as tests for carcinogenicity, developmental including teratogenicity in children and reproductive toxicity, mutagenicity, and neurotoxicity. The increased emphasis on drug carcinogenic toxicity studies is likely to drive the adoption of animal models for in vivo toxicology testing. According to the Cancer Research Institute long term rodent carcinogenicity studies are currently being investigated in order to assess the carcinogenic risk of medications in humans which are propelling the market.


Animal testing alternatives

In the non-animal product development, the use of in vitro models is projected to limit the growth of the in vivo toxicology industry. Such models have acquired widespread acceptance in toxicological testing for human stem cells, pharmaceuticals, cell culture models, and high-throughput testing. Furthermore, the growing use of alternative toxicological testing techniques is likely to reduce need for animal models thereby hindering the market.


Increasing demand for humanised animal models

Humanised animal models are useful instruments for performing preclinical research to learn more about human biology. These models are created by engrafting human cells or tissues into animals, resulting in the expression of human proteins. Humanised mice are increasingly being employed as study models for cancer, infectious illnesses, HIV/AIDS, regenerative medicine, and hepatitis. The rising emphasis on investigating human-specific infections, cures, and diseases, as well as the necessity to discover the actual effects of medications on humans creating wide range of opportunities for the growth of the market.


Animal research regulations and laws

The implementation of animal protection and welfare rules and regulations has resulted in restrictive practises and animal bans for a variety of reasons. Many countries have prohibited the use of animals in the cosmetics sector in the last five years. Furthermore, institutes sponsored by the National Institutes of Health (NIH) are expected to follow Public Health Service (PHS) policy and the Institute for Laboratory Animal Research (ILAR) Guide for the Care and Use of Laboratory Animals. Research institutes seek accreditation from the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC), which halts the market growth.

Covid-19 Impact

The increased focus on COVID-19 vaccine development is expected to create lucrative chances for the market expansion of in vivo toxicology. According to the WHO, 20 vaccines are now in development around the world, with some in the preclinical stage and others having already entered the animal trial phase. Furthermore, the effective use of animal models in COVID-19 research, notably mice models in SARS-CoV-2 replication, is projected to drive market expansion. Despite the prospects presented by the pandemic, existing supply is limited because to animal model producers inability to fulfil increasing demand.

The chronic segment is expected to be the largest during the forecast period

The chronic segment is estimated to have a lucrative growth, due to toxicity testing are performed on at least one rodent and one non-rodent species. The test substance is administered over a period of more than 90 days, and the animals are examined on a regular basis. A chronic toxicological research gives information regarding the long-term effects of a test chemical in animals, which may then be extrapolated to the test substance's safety in humans. As a result, medications used for long-term therapy, such as chemotherapeutic agents, anti-cancer, anti-convulsive, anti-hypertensive, and anti-arthritic therapies, necessitate long-term toxicity testing, driving sector expansion.

The Immunotoxicity segment is expected to have the highest CAGR during the forecast period

The Immunotoxicity segment is anticipated to witness the highest CAGR growth during the forecast period, due to the unfavourable effects on immune system activities produced by excessive medication exposure, biologics, or chemical compound exposure. Human immunosuppression may result from exposure to benzene, asbestos, and halogenated aromatic hydrocarbons.

Region with highest share:

North America is projected to hold the highest market share during the forecast period owing to the high demand for personalised pharmaceuticals is the primary driver of the North American market which includes the United States and Canada. Furthermore, the rise of the Canadian stem cell research sector, which is primarily driven by large-scale expenditures as a result of the implementation of the Canadian Stem Cell Strategy and Action Plan, is a contributing factor to the North America market.

Region with highest CAGR:

Europe is projected to have the highest CAGR over the forecast period, owing to the region's thriving pharmaceutical and biopharmaceutical industries, as well as the increased investment in R&D. However, due to the extensive R&D in the early stages, which is projected to drive the market, the In Vivo Toxicology technique activities are likely to expand in this region.

Key players in the market

Some of the key players profiled in the In Vivo Toxicology Market include The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, Janvier Labs, Thermo Fisher Scientific, Waters Corporation, Danaher Corporation, Shimadzu Corporation, Agilent Technologies, PerkinElmer, Merck KGaA, GE Healthcare, genOway, Bio-Rad Laboratories, Crown Biosciences, Harbour BioMed, Bruker Corporation and TransCure bioServices

Key Developments:

In March 2023, Charles River Launches Apollo™, an industry-leading, secure, cloud-based platform for real-time toxicology study data, the platform’s current capabilities are designed to support clients with safety assessment and toxicology studies.

In Feb 2023, The Jackson Laboratory partners with northwestern to create cardiogenomics course for clinicians, with northwestern university will help clinicians better identify patients at risk for genetic cardiac disease.

In Feb 2023, Charles River Launches Novel IgY-based ELISA Kit for the detection and quantitation of residual host cell protein, this increase in sensitivity and specificity can be attributed to the unique chicken immunoglobulin y (IgY) antibodies utilized.

Products Covered:
• Consumables
• Instruments
• Other Products

Testing Facilities Covered:
• Outsourced Testing Facility
• In-House Testing Facility

Test Types Covered:
• Sub-Acute
• Acute
• Sub-Chronic
• Chronic
• Other Test Types

Toxicity End Points Covered:
• Systemic Toxicity
• Carcinogenicity
• Genotoxicity
• Immunotoxicity
• Developmental & Reproductive Toxicity (DART)
• Other Toxicity Endpoints

End Users Covered:
• Pharmaceutical & Biotechnology Companies
• Contract Research Organizations
• Academic & Research Institutes
• Other End Users

Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o Qatar
o South Africa
o Rest of Middle East & Africa

What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2020, 2021, 2022, 2025, and 2028
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements

Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
o Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances

Table of Contents

1 Executive Summary

2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions

3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 End User Analysis
3.8 Emerging Markets
3.9 Impact of Covid-19

4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry

5 Global In Vivo Toxicology Market, By Product
5.1 Introduction
5.2 Consumables
5.3 Instruments
5.3.1 Animal Models Rat Models Mice Models Other Animal Models
5.4 Other Products

6 Global In Vivo Toxicology Market, By Testing Facility
6.1 Introduction
6.2 Outsourced Testing Facility
6.3 In-House Testing Facility

7 Global In Vivo Toxicology Market, By Test Type
7.1 Introduction
7.2 Sub-Acute
7.3 Acute
7.4 Sub-Chronic
7.5 Chronic
7.6 Other Test Types

8 Global In Vivo Toxicology Market, By Toxicity End Point
8.1 Introduction
8.2 Systemic Toxicity
8.3 Carcinogenicity
8.4 Genotoxicity
8.5 Immunotoxicity
8.6 Developmental & Reproductive Toxicity (DART)
8.7 Other Toxicity Endpoints

9 Global In Vivo Toxicology Market, By End User
9.1 Introduction
9.2 Pharmaceutical & Biotechnology Companies
9.3 Contract Research Organizations
9.4 Academic & Research Institutes
9.5 Other End Users

10 Global In Vivo Toxicology Market, By Geography
10.1 Introduction
10.2 North America
10.2.1 US
10.2.2 Canada
10.2.3 Mexico
10.3 Europe
10.3.1 Germany
10.3.2 UK
10.3.3 Italy
10.3.4 France
10.3.5 Spain
10.3.6 Rest of Europe
10.4 Asia Pacific
10.4.1 Japan
10.4.2 China
10.4.3 India
10.4.4 Australia
10.4.5 New Zealand
10.4.6 South Korea
10.4.7 Rest of Asia Pacific
10.5 South America
10.5.1 Argentina
10.5.2 Brazil
10.5.3 Chile
10.5.4 Rest of South America
10.6 Middle East & Africa
10.6.1 Saudi Arabia
10.6.2 UAE
10.6.3 Qatar
10.6.4 South Africa
10.6.5 Rest of Middle East & Africa

11 Key Developments
11.1 Agreements, Partnerships, Collaborations and Joint Ventures
11.2 Acquisitions & Mergers
11.3 New Product Launch
11.4 Expansions
11.5 Other Key Strategies

12 Company Profiling
12.1 The Jackson Laboratory
12.2 Charles River Laboratories
12.3 Taconic Biosciences
12.4 Janvier Labs
12.5 Thermo Fisher Scientific
12.6 Waters Corporation
12.7 Danaher Corporation
12.8 Shimadzu Corporation
12.9 Agilent Technologies
12.10 PerkinElmer
12.11 Merck KGaA
12.12 GE Healthcare
12.13 genOway
12.14 Bio-Rad Laboratories
12.15 Crown Biosciences
12.16 Harbour BioMed
12.17 Bruker Corporation
12.18 TransCure bioServices

List of Tables
1 Global In Vivo Toxicology Market Outlook, By Region (2020-2028) ($MN)
2 Global In Vivo Toxicology Market Outlook, By Product (2020-2028) ($MN)
3 Global In Vivo Toxicology Market Outlook, By Consumables (2020-2028) ($MN)
4 Global In Vivo Toxicology Market Outlook, By Instruments (2020-2028) ($MN)
5 Global In Vivo Toxicology Market Outlook, By Animal Models (2020-2028) ($MN)
6 Global In Vivo Toxicology Market Outlook, By Rat Models (2020-2028) ($MN)
7 Global In Vivo Toxicology Market Outlook, By Mice Models (2020-2028) ($MN)
8 Global In Vivo Toxicology Market Outlook, By Other Animal Models (2020-2028) ($MN)
9 Global In Vivo Toxicology Market Outlook, By Other Products (2020-2028) ($MN)
10 Global In Vivo Toxicology Market Outlook, By Testing Facility (2020-2028) ($MN)
10 Global In Vivo Toxicology Market Outlook, By Outsourced Testing Facility (2020-2028) ($MN)
11 Global In Vivo Toxicology Market Outlook, By In-House Testing Facility (2020-2028) ($MN)
12 Global In Vivo Toxicology Market Outlook, By Test Type (2020-2028) ($MN)
14 Global In Vivo Toxicology Market Outlook, By Sub-Acute (2020-2028) ($MN)
15 Global In Vivo Toxicology Market Outlook, By Acute (2020-2028) ($MN)
16 Global In Vivo Toxicology Market Outlook, By Sub-Chronic (2020-2028) ($MN)
17 Global In Vivo Toxicology Market Outlook, By Chronic (2020-2028) ($MN)
18 Global In Vivo Toxicology Market Outlook, By Other Test Types (2020-2028) ($MN)
19 Global In Vivo Toxicology Market Outlook, By Toxicity End Point (2020-2028) ($MN)
20 Global In Vivo Toxicology Market Outlook, By Systemic Toxicity (2020-2028) ($MN)
21 Global In Vivo Toxicology Market Outlook, By Carcinogenicity (2020-2028) ($MN)
22 Global In Vivo Toxicology Market Outlook, By Genotoxicity (2020-2028) ($MN)
23 Global In Vivo Toxicology Market Outlook, By Immunotoxicity (2020-2028) ($MN)
24 Global In Vivo Toxicology Market Outlook, By Developmental & Reproductive Toxicity (DART) (2020-2028) ($MN)
25 Global In Vivo Toxicology Market Outlook, By Other Toxicity Endpoints (2020-2028) ($MN)
26 Global In Vivo Toxicology Market Outlook, By End User (2020-2028) ($MN)
27 Global In Vivo Toxicology Market Outlook, By Pharmaceutical & Biotechnology Companies (2020-2028) ($MN)
28 Global In Vivo Toxicology Market Outlook, By Contract Research Organizations (2020-2028) ($MN)
29 Global In Vivo Toxicology Market Outlook, By Academic & Research Institutes (2020-2028) ($MN)
30 Global In Vivo Toxicology Market Outlook, By Other End Users (2020-2028) ($MN)

Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.

List of Figures


Research Methodology

We at Stratistics opt for an extensive research approach which involves data mining, data validation, and data analysis. The various research sources include in-house repository, secondary research, competitor’s sources, social media research, client internal data, and primary research.

Our team of analysts prefers the most reliable and authenticated data sources in order to perform the comprehensive literature search. With access to most of the authenticated data bases our team highly considers the best mix of information through various sources to obtain extensive and accurate analysis.

Each report takes an average time of a month and a team of 4 industry analysts. The time may vary depending on the scope and data availability of the desired market report. The various parameters used in the market assessment are standardized in order to enhance the data accuracy.

Data Mining

The data is collected from several authenticated, reliable, paid and unpaid sources and is filtered depending on the scope & objective of the research. Our reports repository acts as an added advantage in this procedure. Data gathering from the raw material suppliers, distributors and the manufacturers is performed on a regular basis, this helps in the comprehensive understanding of the products value chain. Apart from the above mentioned sources the data is also collected from the industry consultants to ensure the objective of the study is in the right direction.

Market trends such as technological advancements, regulatory affairs, market dynamics (Drivers, Restraints, Opportunities and Challenges) are obtained from scientific journals, market related national & international associations and organizations.

Data Analysis

From the data that is collected depending on the scope & objective of the research the data is subjected for the analysis. The critical steps that we follow for the data analysis include:

  • Product Lifecycle Analysis
  • Competitor analysis
  • Risk analysis
  • Porters Analysis
  • PESTEL Analysis
  • SWOT Analysis

The data engineering is performed by the core industry experts considering both the Marketing Mix Modeling and the Demand Forecasting. The marketing mix modeling makes use of multiple-regression techniques to predict the optimal mix of marketing variables. Regression factor is based on a number of variables and how they relate to an outcome such as sales or profits.

Data Validation

The data validation is performed by the exhaustive primary research from the expert interviews. This includes telephonic interviews, focus groups, face to face interviews, and questionnaires to validate our research from all aspects. The industry experts we approach come from the leading firms, involved in the supply chain ranging from the suppliers, distributors to the manufacturers and consumers so as to ensure an unbiased analysis.

We are in touch with more than 15,000 industry experts with the right mix of consultants, CEO's, presidents, vice presidents, managers, experts from both supply side and demand side, executives and so on.

The data validation involves the primary research from the industry experts belonging to:

  • Leading Companies
  • Suppliers & Distributors
  • Manufacturers
  • Consumers
  • Industry/Strategic Consultants

Apart from the data validation the primary research also helps in performing the fill gap research, i.e. providing solutions for the unmet needs of the research which helps in enhancing the reports quality.

For more details about research methodology, kindly write to us at

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