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In Vivo Toxicology Market Forecasts to 2028 - Global Analysis By Product (Consumables, Instruments and Other Products), Testing Facility (Outsourced Testing Facility and In-House Testing Facility), Test Type (Sub-Acute, Acute, Sub-Chronic, Chronic and Other Test Types), Toxicity End Point, End User and By Geography
Estimated Year Value (2022)
US $5.56 BN
Projected Year Value (2028)
US $7.67 BN
CAGR (2022 - 2028)
North America, Europe, Asia Pacific, South America, and Middle East & Africa
US, Canada, Mexico, Germany, UK, Italy, France, Spain, Japan, China, India, Australia, New Zealand, South Korea, Rest of Asia Pacific, South America, Argentina, Brazil, Chile, Middle East & Africa, Saudi Arabia, UAE, Qatar, and South Africa
Highest Growing Market
According to Stratistics MRC, the Global In Vivo Toxicology Market is accounted for $5.56 billion in 2022 and is expected to reach $7.67 billion by 2028 growing at a CAGR of 5.5% during the forecast period. Vivo toxicology is the study of the toxicity of various medications on a living organism, usually an animal. This is in contrast to in vitro toxicology, which uses non-living technologies like as computer models and cell lines. This type of testing investigates how chemicals and medications affect the behaviour and health of living animals. This data is used in the creation of critical drugs that can help prevent and treat specific human diseases such as cancer and Alzheimer's.
According to the Centers for Disease Control and Prevention (CDC), in 2021, around 18.2 million adults aged 20 and older had coronary artery disease (CAD) in the United States. Heart disease is the leading cause of death among people in the United States.
Unique In vivo toxicological tests
Several toxicological tests are now carried out in laboratories, thanks to the emergence of alternative methodologies such as in vitro and in silico toxicity testing. Certain assays, however, are only available in vivo, such as tests for carcinogenicity, developmental including teratogenicity in children and reproductive toxicity, mutagenicity, and neurotoxicity. The increased emphasis on drug carcinogenic toxicity studies is likely to drive the adoption of animal models for in vivo toxicology testing. According to the Cancer Research Institute long term rodent carcinogenicity studies are currently being investigated in order to assess the carcinogenic risk of medications in humans which are propelling the market.
Animal testing alternatives
In the non-animal product development, the use of in vitro models is projected to limit the growth of the in vivo toxicology industry. Such models have acquired widespread acceptance in toxicological testing for human stem cells, pharmaceuticals, cell culture models, and high-throughput testing. Furthermore, the growing use of alternative toxicological testing techniques is likely to reduce need for animal models thereby hindering the market.
Increasing demand for humanised animal models
Humanised animal models are useful instruments for performing preclinical research to learn more about human biology. These models are created by engrafting human cells or tissues into animals, resulting in the expression of human proteins. Humanised mice are increasingly being employed as study models for cancer, infectious illnesses, HIV/AIDS, regenerative medicine, and hepatitis. The rising emphasis on investigating human-specific infections, cures, and diseases, as well as the necessity to discover the actual effects of medications on humans creating wide range of opportunities for the growth of the market.
Animal research regulations and laws
The implementation of animal protection and welfare rules and regulations has resulted in restrictive practises and animal bans for a variety of reasons. Many countries have prohibited the use of animals in the cosmetics sector in the last five years. Furthermore, institutes sponsored by the National Institutes of Health (NIH) are expected to follow Public Health Service (PHS) policy and the Institute for Laboratory Animal Research (ILAR) Guide for the Care and Use of Laboratory Animals. Research institutes seek accreditation from the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC), which halts the market growth.
The increased focus on COVID-19 vaccine development is expected to create lucrative chances for the market expansion of in vivo toxicology. According to the WHO, 20 vaccines are now in development around the world, with some in the preclinical stage and others having already entered the animal trial phase. Furthermore, the effective use of animal models in COVID-19 research, notably mice models in SARS-CoV-2 replication, is projected to drive market expansion. Despite the prospects presented by the pandemic, existing supply is limited because to animal model producers inability to fulfil increasing demand.
The chronic segment is expected to be the largest during the forecast period
The chronic segment is estimated to have a lucrative growth, due to toxicity testing are performed on at least one rodent and one non-rodent species. The test substance is administered over a period of more than 90 days, and the animals are examined on a regular basis. A chronic toxicological research gives information regarding the long-term effects of a test chemical in animals, which may then be extrapolated to the test substance's safety in humans. As a result, medications used for long-term therapy, such as chemotherapeutic agents, anti-cancer, anti-convulsive, anti-hypertensive, and anti-arthritic therapies, necessitate long-term toxicity testing, driving sector expansion.
The Immunotoxicity segment is expected to have the highest CAGR during the forecast period
The Immunotoxicity segment is anticipated to witness the highest CAGR growth during the forecast period, due to the unfavourable effects on immune system activities produced by excessive medication exposure, biologics, or chemical compound exposure. Human immunosuppression may result from exposure to benzene, asbestos, and halogenated aromatic hydrocarbons.
Region with highest share:
North America is projected to hold the highest market share during the forecast period owing to the high demand for personalised pharmaceuticals is the primary driver of the North American market which includes the United States and Canada. Furthermore, the rise of the Canadian stem cell research sector, which is primarily driven by large-scale expenditures as a result of the implementation of the Canadian Stem Cell Strategy and Action Plan, is a contributing factor to the North America market.
Region with highest CAGR:
Europe is projected to have the highest CAGR over the forecast period, owing to the region's thriving pharmaceutical and biopharmaceutical industries, as well as the increased investment in R&D. However, due to the extensive R&D in the early stages, which is projected to drive the market, the In Vivo Toxicology technique activities are likely to expand in this region.
Key players in the market
Some of the key players profiled in the In Vivo Toxicology Market include The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, Janvier Labs, Thermo Fisher Scientific, Waters Corporation, Danaher Corporation, Shimadzu Corporation, Agilent Technologies, PerkinElmer, Merck KGaA, GE Healthcare, genOway, Bio-Rad Laboratories, Crown Biosciences, Harbour BioMed, Bruker Corporation and TransCure bioServices
In March 2023, Charles River Launches Apollo™, an industry-leading, secure, cloud-based platform for real-time toxicology study data, the platform’s current capabilities are designed to support clients with safety assessment and toxicology studies.
In Feb 2023, The Jackson Laboratory partners with northwestern to create cardiogenomics course for clinicians, with northwestern university will help clinicians better identify patients at risk for genetic cardiac disease.
In Feb 2023, Charles River Launches Novel IgY-based ELISA Kit for the detection and quantitation of residual host cell protein, this increase in sensitivity and specificity can be attributed to the unique chicken immunoglobulin y (IgY) antibodies utilized.
• Other Products
Testing Facilities Covered:
• Outsourced Testing Facility
• In-House Testing Facility
Test Types Covered:
• Other Test Types
Toxicity End Points Covered:
• Systemic Toxicity
• Developmental & Reproductive Toxicity (DART)
• Other Toxicity Endpoints
End Users Covered:
• Pharmaceutical & Biotechnology Companies
• Contract Research Organizations
• Academic & Research Institutes
• Other End Users
• North America
o Rest of Europe
• Asia Pacific
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o South Africa
o Rest of Middle East & Africa
What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2020, 2021, 2022, 2025, and 2028
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements
Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
o Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances
Table of Contents
1 Executive Summary
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
3 Market Trend Analysis
3.6 Product Analysis
3.7 End User Analysis
3.8 Emerging Markets
3.9 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global In Vivo Toxicology Market, By Product
5.3.1 Animal Models
22.214.171.124 Rat Models
126.96.36.199 Mice Models
188.8.131.52 Other Animal Models
5.4 Other Products
6 Global In Vivo Toxicology Market, By Testing Facility
6.2 Outsourced Testing Facility
6.3 In-House Testing Facility
7 Global In Vivo Toxicology Market, By Test Type
7.6 Other Test Types
8 Global In Vivo Toxicology Market, By Toxicity End Point
8.2 Systemic Toxicity
8.6 Developmental & Reproductive Toxicity (DART)
8.7 Other Toxicity Endpoints
9 Global In Vivo Toxicology Market, By End User
9.2 Pharmaceutical & Biotechnology Companies
9.3 Contract Research Organizations
9.4 Academic & Research Institutes
9.5 Other End Users
10 Global In Vivo Toxicology Market, By Geography
10.2 North America
10.3.6 Rest of Europe
10.4 Asia Pacific
10.4.5 New Zealand
10.4.6 South Korea
10.4.7 Rest of Asia Pacific
10.5 South America
10.5.4 Rest of South America
10.6 Middle East & Africa
10.6.1 Saudi Arabia
10.6.4 South Africa
10.6.5 Rest of Middle East & Africa
11 Key Developments
11.1 Agreements, Partnerships, Collaborations and Joint Ventures
11.2 Acquisitions & Mergers
11.3 New Product Launch
11.5 Other Key Strategies
12 Company Profiling
12.1 The Jackson Laboratory
12.2 Charles River Laboratories
12.3 Taconic Biosciences
12.4 Janvier Labs
12.5 Thermo Fisher Scientific
12.6 Waters Corporation
12.7 Danaher Corporation
12.8 Shimadzu Corporation
12.9 Agilent Technologies
12.11 Merck KGaA
12.12 GE Healthcare
12.14 Bio-Rad Laboratories
12.15 Crown Biosciences
12.16 Harbour BioMed
12.17 Bruker Corporation
12.18 TransCure bioServices
List of Tables
1 Global In Vivo Toxicology Market Outlook, By Region (2020-2028) ($MN)
2 Global In Vivo Toxicology Market Outlook, By Product (2020-2028) ($MN)
3 Global In Vivo Toxicology Market Outlook, By Consumables (2020-2028) ($MN)
4 Global In Vivo Toxicology Market Outlook, By Instruments (2020-2028) ($MN)
5 Global In Vivo Toxicology Market Outlook, By Animal Models (2020-2028) ($MN)
6 Global In Vivo Toxicology Market Outlook, By Rat Models (2020-2028) ($MN)
7 Global In Vivo Toxicology Market Outlook, By Mice Models (2020-2028) ($MN)
8 Global In Vivo Toxicology Market Outlook, By Other Animal Models (2020-2028) ($MN)
9 Global In Vivo Toxicology Market Outlook, By Other Products (2020-2028) ($MN)
10 Global In Vivo Toxicology Market Outlook, By Testing Facility (2020-2028) ($MN)
10 Global In Vivo Toxicology Market Outlook, By Outsourced Testing Facility (2020-2028) ($MN)
11 Global In Vivo Toxicology Market Outlook, By In-House Testing Facility (2020-2028) ($MN)
12 Global In Vivo Toxicology Market Outlook, By Test Type (2020-2028) ($MN)
14 Global In Vivo Toxicology Market Outlook, By Sub-Acute (2020-2028) ($MN)
15 Global In Vivo Toxicology Market Outlook, By Acute (2020-2028) ($MN)
16 Global In Vivo Toxicology Market Outlook, By Sub-Chronic (2020-2028) ($MN)
17 Global In Vivo Toxicology Market Outlook, By Chronic (2020-2028) ($MN)
18 Global In Vivo Toxicology Market Outlook, By Other Test Types (2020-2028) ($MN)
19 Global In Vivo Toxicology Market Outlook, By Toxicity End Point (2020-2028) ($MN)
20 Global In Vivo Toxicology Market Outlook, By Systemic Toxicity (2020-2028) ($MN)
21 Global In Vivo Toxicology Market Outlook, By Carcinogenicity (2020-2028) ($MN)
22 Global In Vivo Toxicology Market Outlook, By Genotoxicity (2020-2028) ($MN)
23 Global In Vivo Toxicology Market Outlook, By Immunotoxicity (2020-2028) ($MN)
24 Global In Vivo Toxicology Market Outlook, By Developmental & Reproductive Toxicity (DART) (2020-2028) ($MN)
25 Global In Vivo Toxicology Market Outlook, By Other Toxicity Endpoints (2020-2028) ($MN)
26 Global In Vivo Toxicology Market Outlook, By End User (2020-2028) ($MN)
27 Global In Vivo Toxicology Market Outlook, By Pharmaceutical & Biotechnology Companies (2020-2028) ($MN)
28 Global In Vivo Toxicology Market Outlook, By Contract Research Organizations (2020-2028) ($MN)
29 Global In Vivo Toxicology Market Outlook, By Academic & Research Institutes (2020-2028) ($MN)
30 Global In Vivo Toxicology Market Outlook, By Other End Users (2020-2028) ($MN)
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.
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