
Protein Purification And Isolation Market
Protein Purification and Isolation Market Forecasts to 2028 - Global Analysis By Product (Instruments and Consumables), Technology (Ultrafiltration, Precipitation, Preparative Chromatography, Electrophoresis, Western Blotting, Dialysis & Diafiltration and Centrifugation), Application (Biomarker Discovery, Disease Diagnostics & Monitoring, Drug Screening and Other Applications), End User and By Geography

Years Covered |
2020-2028 |
Estimated Year Value (2022) |
US $8.24 BN |
Projected Year Value (2028) |
US $17.40 BN |
CAGR (2022 - 2028) |
13.26% |
Regions Covered |
North America, Europe, Asia Pacific, South America, and Middle East & Africa |
Countries Covered |
US, Canada, Mexico, Germany, UK, Italy, France, Spain, Japan, China, India, Australia, New Zealand, South Korea, Rest of Asia Pacific, South America, Argentina, Brazil, Chile, Middle East & Africa, Saudi Arabia, UAE, Qatar, and South Africa |
Largest Market |
North America |
Highest Growing Market |
Asia Pacific |
According to Stratistics MRC, the Global Protein Purification and Isolation Market is accounted for $8.24 billion in 2022 and is expected to reach $17.40 billion by 2028 growing at a CAGR of 13.26% during the forecast period. Protein purification is the process of removing proteins using physical differences from complex mixtures of cells, tissues, or organisms. Large amounts of functional protein with few impurities are sought after by the protein purification procedure. In order to obtain the desired protein, the process separates proteins from non-protein components in a mixture. They are primarily used to categorize the protein's structure, function, and interactions. Affinity chromatography, immunoprecipitation, proteomics, or enzyme assays are a few of the frequently employed techniques for protein purification and isolation.
According to the report published by the Research America in January 2022, the biopharmaceutical companies invested around USD 122,204 million in 2020, wheras in 2019 the investment was around USD 110,932 million in R&D. Therefore, such fact is anticipated to drive the growth of the market in the country.
Market Dynamics:
Driver:
Increasing demand for rapid purification kits
One of the main factors fueling market expansion is the growing importance of discovering novel ligands, such as protein-based therapeutic compounds. The global protein purification and isolation market is being driven by the increasing demand for rapid purification kits to quickly screen, prepare, purify, and concentrate protein samples. The market is also expected to grow as a result of a number of factors, including increased funding from both public and private research organizations for R&D and expanding research in structure-based drug design.
Restraint:
High costs and time consuming process
Techniques for protein purification and isolation frequently require specialized tools, reagents, and personnel, which raises the overall cost. For researchers and institutions with limited resources, this may limit their access to these techniques. Additionally, the process of purifying and isolating proteins can be time-consuming and involve numerous steps, including cell lysis, chromatography, and filtration. Protein purification may be less effective and less scalable as a result of the drawn-out processes.
Opportunity:
Rising investments by governments
Increased government investments in R&D and programs fostering their growth and expansion benefit the pharmaceutical and biotechnology industries. Additionally, they offer benefits in the form of grants, regulations, and tax breaks. Due to the significant investments made in studying and creating molecules specific to biomarkers, the pharmaceutical industry is a very lucrative market for goods involving protein purification and isolation.
Threat:
Lack of universal purification techniques and regulatory requirements
Regulatory requirements and quality standards may apply to the protein purification and isolation process, particularly when it is used in biotechnology or pharmaceutical applications. The process as a whole may become more complicated and expensive due to compliance with these requirements. Additionally, there isn't a purification technique that can successfully isolate and purify every kind of protein. The process becomes more complex and variable as a result of the potential need for different proteins to be purified using specific methods tailored to their individual characteristics.
Covid-19 Impact
The protein purification and isolation market was negatively impacted by the supply chain disruption caused by COVID-19 and the delay in the delivery of crucial goods needed for the production of the kits, reagents, and consumables used in protein purification and isolation. A pandemic presents the market with a number of significant challenges, such as trucking bottlenecks and port checkpoints that slow down deliveries of essential supplies, export bans imposed in many nations, a dearth of operational manufacturing facilities, and a shortage of healthcare workers to transport and produce goods. As a result, this situation initially prevented market growth. The use of protein purification and isolation techniques for analysis and research involving the ever-emerging acute respiratory syndrome coronavirus (SARS-CoV-2) has, however, led to an increase in demand in recent years.
The consumables segment is expected to be the largest during the forecast period
During the forecast period, the consumables segment is anticipated to hold the largest market share for protein purification and isolation. The significant market share of this sector is primarily attributable to the frequent use of consumables for protein purification and the attention paid to the development of biopharmaceuticals by a variety of end users, including academic and medical research institutions and pharmaceutical firms.
The ultrafiltration segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the ultrafiltration segment is anticipated to grow at the highest rate. Ultrafiltration is a technique used to remove dissolved molecules and incredibly small particles from liquids. The size of the molecules serves as the main basis for separation, though the sample's chemical, molecular, or electrostatic properties may also have an impact on the filter's permeability. Proteins and buffer components are typically separated using ultrafiltration for buffer exchange, concentration, or desalination. Ultrafiltration's benefits and widespread use in protein purification and isolation are the primary factors driving the segment's growth over the forecast period.
Region with largest share:
The presence of numerous protein purification market players, a developed research and development infrastructure, and technological developments in the proteomics sector all contribute to North America's continued dominance of the global protein purification market over the forecast period. The demand for technologically advanced protein isolation technologies in the North American market is also being driven by improved application fields like protein-protein interaction studies, target identification, drug screening, protein therapeutics, biomarker discovery, disease monitoring, and diagnostic tests.
Region with highest CAGR:
Over the forecast period, Asia-Pacific is anticipated to experience lucrative growth. The demand for protein purification and isolation solutions in this region is expected to be driven by government initiatives for the development of healthcare infrastructure in developing nations like China and India. Moreover, these governments are funding the creation of cutting-edge purification and isolation techniques. Additionally, initiatives promoting domestic pharmaceutical production and the high volume of biosimilar production contribute to the market's expansion.
Key players in the market
Some of the key players profiled in the Protein Purification and Isolation Market include Abcam plc, Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Danaher, G.E. Healthcare Life Sciences, Kamada Ltd., Lanleys International Inc., Leaf Expression Systems, Major Science, Merck KGaA, MNPHARM, Mtibio, Noble Life Sciences, Inc., Norgen Biotek Corporation, Promega Corporation, Qiagen N.V., Sigma-Aldrich Corporation, Takara Bio Inc and Thermo Fischer Scientific, Inc.
Key Developments:
In June 2022, Merck and Mulliken Center for Theoretical Chemistry Collaborated in Machine Learning Project. The three-year collaboration will focus on developing new tools for computational chemistry modeling and new molecular representations.
In April 2022, Thermo Fisher Scientific Enhanced Clinical Research Solutions in Collaboration with Matrix Clinical Trials. The PPD clinical research business of Thermo Fisher Scientific Inc., the world leader in serving science, and Matrix Clinical Trials, a Matrix Medical Network offering, collaborated to bring clinical trials to patients with an innovative decentralized clinical trial (DCT) solution.
Products Covered:
• Instruments
• Consumables
Technologies Covered:
• Ultrafiltration
• Precipitation
• Preparative Chromatography
• Electrophoresis
• Western Blotting
• Dialysis & Diafiltration
• Centrifugation
Applications Covered:
• Biomarker Discovery
• Disease Diagnostics & Monitoring
• Drug Screening
• Protein Therapeutics
• Protein-Protein Interaction Studies
• Target Identification
End Users Covered:
• Academic Medical Institutes
• Hospitals & Diagnostics Centers
• Pharmaceutical & Biotechnology Companies
• Contract Research Organizations (CROs)
Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o UAE
o Qatar
o South Africa
o Rest of Middle East & Africa
What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2020, 2021, 2022, 2025, and 2028
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements
Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
o Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances
Table of Contents
1 Executive Summary
2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions
3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 Technology Analysis
3.8 Application Analysis
3.9 End User Analysis
3.10 Emerging Markets
3.11 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global Protein Purification and Isolation Market, By Product
5.1 Introduction
5.2 Instruments
5.3 Consumables
5.3.1 Prepacked Columns
5.3.2 Protein Purification Kits
5.3.3 Protein Purification Resins
5.3.4 Reagents
5.3.5 Magnetic Beads
5.3.5.1 Tagged Magnetic Beads
5.3.5.2 Non-tagged Magnetic Beads
5.3.6 Other Consumables
6 Global Protein Purification and Isolation Market, By Technology
6.1 Introduction
6.2 Ultrafiltration
6.3 Precipitation
6.4 Preparative Chromatography
6.4.1 Affinity Chromatography
6.4.2 Immobilized Metal Ion Affinity Chromatography (IMAC)
6.4.3 Immunoaffinity Chromatography (IAC)
6.4.4 Bead-Based Chromatography
6.4.5 Ion Exchange Chromatography
6.4.6 Reverse-Phase Chromatography
6.4.7 Hydrophobic Charge Induction Chromatography
6.4.8 Size Exclusion Chromatography
6.5 Electrophoresis
6.5.1 Gel Electrophoresis
6.5.2 Isoelectric Focusing Electrophoresis
6.5.3 Capillary Electrophoresis
6.6 Western Blotting
6.7 Dialysis & Diafiltration
6.8 Centrifugation
7 Global Protein Purification and Isolation Market, By Application
7.1 Introduction
7.2 Biomarker Discovery
7.3 Disease Diagnostics & Monitoring
7.4 Drug Screening
7.5 Protein Therapeutics
7.6 Protein-Protein Interaction Studies
7.7 Target Identification
8 Global Protein Purification and Isolation Market, By End User
8.1 Introduction
8.2 Academic Medical Institutes
8.3 Hospitals & Diagnostics Centers
8.4 Pharmaceutical & Biotechnology Companies
8.5 Contract Research Organizations (CROs)
9 Global Protein Purification and Isolation Market, By Geography
9.1 Introduction
9.2 North America
9.2.1 US
9.2.2 Canada
9.2.3 Mexico
9.3 Europe
9.3.1 Germany
9.3.2 UK
9.3.3 Italy
9.3.4 France
9.3.5 Spain
9.3.6 Rest of Europe
9.4 Asia Pacific
9.4.1 Japan
9.4.2 China
9.4.3 India
9.4.4 Australia
9.4.5 New Zealand
9.4.6 South Korea
9.4.7 Rest of Asia Pacific
9.5 South America
9.5.1 Argentina
9.5.2 Brazil
9.5.3 Chile
9.5.4 Rest of South America
9.6 Middle East & Africa
9.6.1 Saudi Arabia
9.6.2 UAE
9.6.3 Qatar
9.6.4 South Africa
9.6.5 Rest of Middle East & Africa
10 Key Developments
10.1 Agreements, Partnerships, Collaborations and Joint Ventures
10.2 Acquisitions & Mergers
10.3 New Product Launch
10.4 Expansions
10.5 Other Key Strategies
11 Company Profiling
11.1 Abcam plc
11.2 Agilent Technologies, Inc.
11.3 Bio-Rad Laboratories, Inc.
11.4 Danaher
11.5 G.E. Healthcare Life Sciences
11.6 Kamada Ltd.
11.7 Lanleys International Inc.
11.8 Leaf Expression Systems
11.9 Major Science
11.10 Merck KGaA
11.11 MNPHARM
11.12 Mtibio
11.13 Noble Life Sciences, Inc.
11.14 Norgen Biotek Corporation
11.15 Promega Corporation
11.16 Qiagen N.V.
11.17 Sigma-Aldrich Corporation
11.18 Takara Bio Inc
11.19 Thermo Fischer Scientific, Inc.
List of Tables
1 Global Protein Purification and Isolation Market Outlook, By Region (2020-2028) ($MN)
2 Global Protein Purification and Isolation Market Outlook, By Product (2020-2028) ($MN)
3 Global Protein Purification and Isolation Market Outlook, By Instruments (2020-2028) ($MN)
4 Global Protein Purification and Isolation Market Outlook, By Consumables (2020-2028) ($MN)
5 Global Protein Purification and Isolation Market Outlook, By Prepacked Columns (2020-2028) ($MN)
6 Global Protein Purification and Isolation Market Outlook, By Protein Purification Kits (2020-2028) ($MN)
7 Global Protein Purification and Isolation Market Outlook, By Protein Purification Resins (2020-2028) ($MN)
8 Global Protein Purification and Isolation Market Outlook, By Reagents (2020-2028) ($MN)
9 Global Protein Purification and Isolation Market Outlook, By Magnetic Beads (2020-2028) ($MN)
10 Global Protein Purification and Isolation Market Outlook, By Other Consumables (2020-2028) ($MN)
11 Global Protein Purification and Isolation Market Outlook, By Technology (2020-2028) ($MN)
12 Global Protein Purification and Isolation Market Outlook, By Ultrafiltration (2020-2028) ($MN)
13 Global Protein Purification and Isolation Market Outlook, By Precipitation (2020-2028) ($MN)
14 Global Protein Purification and Isolation Market Outlook, By Preparative Chromatography (2020-2028) ($MN)
15 Global Protein Purification and Isolation Market Outlook, By Affinity Chromatography (2020-2028) ($MN)
16 Global Protein Purification and Isolation Market Outlook, By Immobilized Metal Ion Affinity Chromatography (IMAC) (2020-2028) ($MN)
17 Global Protein Purification and Isolation Market Outlook, By Immunoaffinity Chromatography (IAC) (2020-2028) ($MN)
18 Global Protein Purification and Isolation Market Outlook, By Bead-Based Chromatography (2020-2028) ($MN)
19 Global Protein Purification and Isolation Market Outlook, By Ion Exchange Chromatography (2020-2028) ($MN)
20 Global Protein Purification and Isolation Market Outlook, By Reverse-Phase Chromatography (2020-2028) ($MN)
21 Global Protein Purification and Isolation Market Outlook, By Hydrophobic Charge Induction Chromatography (2020-2028) ($MN)
22 Global Protein Purification and Isolation Market Outlook, By Size Exclusion Chromatography (2020-2028) ($MN)
23 Global Protein Purification and Isolation Market Outlook, By Electrophoresis (2020-2028) ($MN)
24 Global Protein Purification and Isolation Market Outlook, By Gel Electrophoresis (2020-2028) ($MN)
25 Global Protein Purification and Isolation Market Outlook, By Isoelectric Focusing Electrophoresis (2020-2028) ($MN)
26 Global Protein Purification and Isolation Market Outlook, By Capillary Electrophoresis (2020-2028) ($MN)
27 Global Protein Purification and Isolation Market Outlook, By Western Blotting (2020-2028) ($MN)
28 Global Protein Purification and Isolation Market Outlook, By Dialysis & Diafiltration (2020-2028) ($MN)
29 Global Protein Purification and Isolation Market Outlook, By Centrifugation (2020-2028) ($MN)
30 Global Protein Purification and Isolation Market Outlook, By Application (2020-2028) ($MN)
31 Global Protein Purification and Isolation Market Outlook, By Biomarker Discovery (2020-2028) ($MN)
32 Global Protein Purification and Isolation Market Outlook, By Disease Diagnostics & Monitoring (2020-2028) ($MN)
33 Global Protein Purification and Isolation Market Outlook, By Drug Screening (2020-2028) ($MN)
34 Global Protein Purification and Isolation Market Outlook, By Protein Therapeutics (2020-2028) ($MN)
35 Global Protein Purification and Isolation Market Outlook, By Protein-Protein Interaction Studies (2020-2028) ($MN)
36 Global Protein Purification and Isolation Market Outlook, By Target Identification (2020-2028) ($MN)
37 Global Protein Purification and Isolation Market Outlook, By End User (2020-2028) ($MN)
38 Global Protein Purification and Isolation Market Outlook, By Academic Medical Institutes (2020-2028) ($MN)
39 Global Protein Purification and Isolation Market Outlook, By Hospitals & Diagnostics Centers (2020-2028) ($MN)
40 Global Protein Purification and Isolation Market Outlook, By Pharmaceutical & Biotechnology Companies (2020-2028) ($MN)
41 Global Protein Purification and Isolation Market Outlook, By Contract Research Organizations (CROs) (2020-2028) ($MN)
Note: Tables for North America, Europe, Asia Pacific, South America and Middle East & Africa Regions are also represented in the same manner as above.
List of Figures
RESEARCH METHODOLOGY

We at ‘Stratistics’ opt for an extensive research approach which involves data mining, data validation, and data analysis. The various research sources include in-house repository, secondary research, competitor’s sources, social media research, client internal data, and primary research.
Our team of analysts prefers the most reliable and authenticated data sources in order to perform the comprehensive literature search. With access to most of the authenticated data bases our team highly considers the best mix of information through various sources to obtain extensive and accurate analysis.
Each report takes an average time of a month and a team of 4 industry analysts. The time may vary depending on the scope and data availability of the desired market report. The various parameters used in the market assessment are standardized in order to enhance the data accuracy.
Data Mining
The data is collected from several authenticated, reliable, paid and unpaid sources and is filtered depending on the scope & objective of the research. Our reports repository acts as an added advantage in this procedure. Data gathering from the raw material suppliers, distributors and the manufacturers is performed on a regular basis, this helps in the comprehensive understanding of the products value chain. Apart from the above mentioned sources the data is also collected from the industry consultants to ensure the objective of the study is in the right direction.
Market trends such as technological advancements, regulatory affairs, market dynamics (Drivers, Restraints, Opportunities and Challenges) are obtained from scientific journals, market related national & international associations and organizations.
Data Analysis
From the data that is collected depending on the scope & objective of the research the data is subjected for the analysis. The critical steps that we follow for the data analysis include:
- Product Lifecycle Analysis
- Competitor analysis
- Risk analysis
- Porters Analysis
- PESTEL Analysis
- SWOT Analysis
The data engineering is performed by the core industry experts considering both the Marketing Mix Modeling and the Demand Forecasting. The marketing mix modeling makes use of multiple-regression techniques to predict the optimal mix of marketing variables. Regression factor is based on a number of variables and how they relate to an outcome such as sales or profits.
Data Validation
The data validation is performed by the exhaustive primary research from the expert interviews. This includes telephonic interviews, focus groups, face to face interviews, and questionnaires to validate our research from all aspects. The industry experts we approach come from the leading firms, involved in the supply chain ranging from the suppliers, distributors to the manufacturers and consumers so as to ensure an unbiased analysis.
We are in touch with more than 15,000 industry experts with the right mix of consultants, CEO's, presidents, vice presidents, managers, experts from both supply side and demand side, executives and so on.
The data validation involves the primary research from the industry experts belonging to:
- Leading Companies
- Suppliers & Distributors
- Manufacturers
- Consumers
- Industry/Strategic Consultants
Apart from the data validation the primary research also helps in performing the fill gap research, i.e. providing solutions for the unmet needs of the research which helps in enhancing the reports quality.
For more details about research methodology, kindly write to us at info@strategymrc.com
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