Cryo Electron Microscopy
Cryo-Electron Microscopy Market Forecasts to 2030 - Global Analysis By Product Type (Instruments, Software, Services and Other Product Types), Method (Cryo-electron Tomography, Electron Crystallography, Single Particle Analysis (SPA) and Other Methods), Nano Formulations, Voltage, Technology, Application and By Geography
According to Stratistics MRC, the Global Cryo-Electron Microscopy Market is accounted for $1.42 billion in 2024 and is expected to reach $3.05 billion by 2030 growing at a CAGR of 13.60% during the forecast period. Due to its ability to enable researchers to see bio molecular structures in unprecedented detail, cryo-electron microscopy, or cryo-EM, has completely changed the field of structural biology. Using an electron microscope at extremely low temperatures, samples are imaged using this technique, which involves rapidly freezing them to preserve their natural state. High-resolution images of biological macromolecules in their natural habitat can be obtained using cryo-EM without the need for chemical fixation or staining. Moreover, significant advancements in the domains of biochemistry, pharmacology, and virology have resulted from its capacity to capture dynamic molecular structures.
According to the World Health Organization (WHO), access to essential medicines is a fundamental human right, and ensuring equitable distribution and affordability of these medicines is critical for achieving global health goals.
Market Dynamics:
Driver:
Growing need for drug development and discovery
Cryo-EM has become a potent tool in the pharmaceutical industry for lead optimization, structural elucidation of drug targets, and rational drug design. The capacity to observe dynamic protein-drug interactions and macromolecular complexes at near-atomic resolution provides significant insight into the potential therapeutics' mechanisms of action. Additionally, Cryo-EM services and expertise are in high demand as drug discovery pipelines shift to focus more on biologics, membrane proteins, and difficult drug targets, which is driving market expansion.
Restraint:
Complexity of data analysis and sample preparation
The preparation of grids, vitrification, and imaging conditions for cryo-EM samples necessitates specific knowledge and tools. A major barrier to entry for inexperienced users is the laborious and complicated workflows involved in sample preparation, in addition to the requirement for proficiency in data analysis and cryo-EM techniques. Furthermore, cryo-EM experiments produce massive amounts of raw data, which calls for sophisticated image processing algorithms and a reliable computing infrastructure for data analysis and structural refinement.
Opportunity:
Technological progress in hardware and software
There are many chances for businesses to be creative and provide cutting-edge cryo-EM hardware and software. This involves developing and producing next-generation electron microscopes with enhanced automation, sensitivity, and resolution. Moreover, there is a growing need for user-friendly software platforms for image processing, data acquisition, and structural analysis. This presents opportunities for software developers to create tools that are efficient and easy to use, which can improve the user experience and streamline the cryo-EM workflow.
Threat:
Market saturation and competitive pressures
There are a growing number of manufacturers, service providers, and research institutions offering cryo-EM solutions, which is congesting the cryo-EM market. Price wars, shrinking profit margins, and the commoditization of cryo-EM goods and services are possible outcomes of fierce competition. Additionally, the industry may experience slower revenue growth, lower profitability, and more industry consolidation as a result of market saturation, as smaller firms find it more difficult to compete with more established, larger firms.
Covid-19 Impact:
The cryo-electron microscopy (cryo-EM) market has been impacted by the COVID-19 pandemic in a number of ways. The pandemic increased demand for cryo-EM in researching the virus's structure, host interactions, and drug development, even though it initially disrupted supply chains, manufacturing operations, and research activities, causing delays in instrument installations, service contracts, and cooperative projects. Cryo-EM has become widely used in COVID-19 research due to the pressing need to comprehend the molecular mechanisms of SARS-CoV-2 and expedite the development of vaccines, therapeutics, and diagnostics. Moreover, the adoption of cloud-based cryo-EM data analysis platforms and remote access solutions has been accelerated by the shift towards remote work and virtual collaboration.
The Lipid Nanoparticle Formulations (LNFS) segment is expected to be the largest during the forecast period
Due to their extensive application in the delivery of genetic materials like mRNA for vaccines and therapeutics, Lipid Nanoparticle Formulations (LNFs) command the largest market share in cryo-electron microscopy (Cryo-EM). These lipid nanoparticles can be imaged at high resolution using cryo-electron microscopy (Cryo-EM), providing information about their size, composition, and structural honesty. Additionally, advanced pharmaceutical development requires the use of liposome-forming factors (LNFs) due to their biocompatibility and capacity to encapsulate and safeguard delicate payloads.
The Transmission Electron Microscopy (TEM) segment is expected to have the highest CAGR during the forecast period
The transmission electron microscopy (TEM) segment is expected to have the highest CAGR in the cryo-electron microscopy (Cryo-EM) market. The need for high-resolution imaging and structural analysis of biological macromolecules is growing, and this growth is being driven by the need to advance materials science, structural biology, and drug discovery. Furthermore, researchers attempting to comprehend intricate biological processes and molecular structures find that TEM is invaluable due to its capacity to produce detailed images at the atomic level in their native state, especially when used in conjunction with cryo-TEM.
Region with largest share:
The market for cryo-electron microscopy, or cryo-EM, is dominated by North America due in large part to the region's concentration of major industry players, solid infrastructure for research, and large investments in cutting-edge technology. The region's emphasis on science and technology, along with strong funding initiatives from both public and private entities, drives advancements in the use of cryo-EM in a variety of fields, such as materials science, pharmaceuticals, and structural biology. Moreover, the concentration of top academic institutions and biopharmaceutical firms encourages cooperation and creativity, which strengthens North America's position as the market leader for cryo-EM products.
Region with highest CAGR:
The cryo-electron microscopy (Cryo-EM) market is growing at the highest CAGR in the Asia-Pacific region due to rapid industrialization, rising R&D spending, and a growing uptake of cutting-edge technologies in a variety of industries. The demand for cryo-EM solutions is driven by the region's growing biotechnology and pharmaceutical industries as well as growing government initiatives to support scientific research and innovation. Additionally, cryo-EM market growth in the Asia-Pacific region is further accelerated by the presence of a large pool of highly skilled researchers and scientists, as well as partnerships with international organizations and academia.
Key players in the market
Some of the key players in Cryo-Electron Microscopy market include Charles River Laboratories, Hitachi High-Technologies Corporation, Intertek Group Plc, Caliber Imaging & Diagnostics, Lasertec Corporation, HORIBA, Ltd, Olympus Corporation, Gatan, Inc., JEOL Ltd, Oxford Instruments, Nikon Instruments Inc, Keyence Corporation, Helmut Hund Gmbh, Danaher, Creative Biostructure, ZEISS International and Thermo Fisher Scientific.
Key Developments:
In May 2024, Intertek announced an agreement to acquire Base Metallurgical Laboratories and Base Met Labs US on Monday, which provides metallurgical testing services within the minerals sector in North America, for an undisclosed sum. The AIM-traded firm said the acquisition came ahead of expected heightened demand for diverse energy sources and minerals to sustain a growing global population.
In May 2024, Hitachi High-Tech and Roche have extended their partnership, committing to at least 10 years of additional collaboration. Bringing together the companies' expertise and track record in diagnostics innovation, engineering and manufacturing, the renewed contract further strengthens the two companies' long lasting partnership.
In February 2024, Charles River Laboratories International, Inc. announced a strategic agreement with Wheeler Bio, Inc., an antibody contract development and manufacturing organization (CDMO) focused on preclinical and early clinical supply of recombinant proteins, providing clients access to Wheeler’s Portable CMC platform.
Product Types Covered:
• Instruments
• Software
• Services
• Other Product Types
Methods Covered:
• Cryo-electron Tomography
• Electron Crystallography
• Single Particle Analysis (SPA)
• Other Methods
Nano Formulations Covered:
• Lipid Nanoparticle Formulations (LNFS)
• Metal Oxide Formulations
• Metal Formulations
• Other Nano Formulations
Voltages Covered:
• 300 kV
• 200 kV
• 120 kV
Technologies Covered:
• Transmission Electron Microscopy (TEM)
• Scanning Electron Microscopy (SEM)
• Nuclear Magnetic Resonance (NMR) Microscopy
• Other Technologies
Applications Covered:
• Life Science Research and Academia
• Cancer Research
• Omics Research
• Pharma and Biotech Manufacturing
• Cell and Gene Therapy
• Pathology
• Preclinical and Clinical Research
• Healthcare/Medical Applications
• Disease Diagnosis and Pathology
• Toxicology Studies
• Material Analysis
• Nanotechnology
• Clinical Trials
• Other Applications
Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o UAE
o Qatar
o South Africa
o Rest of Middle East & Africa
What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2022, 2023, 2024, 2026, and 2030
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements
Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances
Table of Contents
1 Executive Summary
2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions
3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 Technology Analysis
3.8 Application Analysis
3.9 Emerging Markets
3.10 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global Cryo-Electron Microscopy Market, By Product Type
5.1 Introduction
5.2 Instruments
5.2.1 Fully Automated
5.2.2 Semi-automated
5.3 Software
5.4 Services
5.5 Other Product Types
6 Global Cryo-Electron Microscopy Market, By Method
6.1 Introduction
6.2 Cryo-electron Tomography
6.3 Electron Crystallography
6.4 Single Particle Analysis (SPA)
6.5 Other Methods
7 Global Cryo-Electron Microscopy Market, By Nano Formulations
7.1 Introduction
7.2 Lipid Nanoparticle Formulations (LNFS)
7.3 Metal Oxide Formulations
7.4 Metal Formulations
7.5 Other Nano Formulations
8 Global Cryo-Electron Microscopy Market, By Voltage
8.1 Introduction
8.2 300 kV
8.3 200 kV
8.4 120 kV
9 Global Cryo-Electron Microscopy Market, By Technology
9.1 Introduction
9.2 Transmission Electron Microscopy (TEM)
9.3 Scanning Electron Microscopy (SEM)
9.4 Nuclear Magnetic Resonance (NMR) Microscopy
9.5 Other Technologies
10 Global Cryo-Electron Microscopy Market, By Application
10.1 Introduction
10.2 Life Science Research and Academia
10.3 Cancer Research
10.4 Omics Research
10.5 Pharma and Biotech Manufacturing
10.6 Cell and Gene Therapy
10.7 Pathology
10.8 Preclinical and Clinical Research
10.9 Healthcare/Medical Applications
10.10 Disease Diagnosis and Pathology
10.11 Toxicology Studies
10.12 Material Analysis
10.13 Nanotechnology
10.14 Clinical Trials
10.15 Other Applications
11 Global Cryo-Electron Microscopy Market, By Geography
11.1 Introduction
11.2 North America
11.2.1 US
11.2.2 Canada
11.2.3 Mexico
11.3 Europe
11.3.1 Germany
11.3.2 UK
11.3.3 Italy
11.3.4 France
11.3.5 Spain
11.3.6 Rest of Europe
11.4 Asia Pacific
11.4.1 Japan
11.4.2 China
11.4.3 India
11.4.4 Australia
11.4.5 New Zealand
11.4.6 South Korea
11.4.7 Rest of Asia Pacific
11.5 South America
11.5.1 Argentina
11.5.2 Brazil
11.5.3 Chile
11.5.4 Rest of South America
11.6 Middle East & Africa
11.6.1 Saudi Arabia
11.6.2 UAE
11.6.3 Qatar
11.6.4 South Africa
11.6.5 Rest of Middle East & Africa
12 Key Developments
12.1 Agreements, Partnerships, Collaborations and Joint Ventures
12.2 Acquisitions & Mergers
12.3 New Product Launch
12.4 Expansions
12.5 Other Key Strategies
13 Company Profiling
13.1 Charles River Laboratories
13.2 Hitachi High-Technologies Corporation
13.3 Intertek Group Plc
13.4 Caliber Imaging & Diagnostics
13.5 Lasertec Corporation
13.6 HORIBA, Ltd
13.7 Olympus Corporation
13.8 Gatan, Inc.
13.9 JEOL Ltd
13.10 Oxford Instruments
13.11 Nikon Instruments Inc
13.12 Keyence Corporation
13.13 Helmut Hund Gmbh
13.14 Danaher
13.15 Creative Biostructure
13.16 ZEISS International
13.17 Thermo Fisher Scientific
List of Tables
1 Global Cryo-Electron Microscopy Market Outlook, By Region (2022-2030) ($MN)
2 Global Cryo-Electron Microscopy Market Outlook, By Product Type (2022-2030) ($MN)
3 Global Cryo-Electron Microscopy Market Outlook, By Instruments (2022-2030) ($MN)
4 Global Cryo-Electron Microscopy Market Outlook, By Fully Automated (2022-2030) ($MN)
5 Global Cryo-Electron Microscopy Market Outlook, By Semi-automated (2022-2030) ($MN)
6 Global Cryo-Electron Microscopy Market Outlook, By Software (2022-2030) ($MN)
7 Global Cryo-Electron Microscopy Market Outlook, By Services (2022-2030) ($MN)
8 Global Cryo-Electron Microscopy Market Outlook, By Other Product Types (2022-2030) ($MN)
9 Global Cryo-Electron Microscopy Market Outlook, By Method (2022-2030) ($MN)
10 Global Cryo-Electron Microscopy Market Outlook, By Cryo-electron Tomography (2022-2030) ($MN)
11 Global Cryo-Electron Microscopy Market Outlook, By Electron Crystallography (2022-2030) ($MN)
12 Global Cryo-Electron Microscopy Market Outlook, By Single Particle Analysis (SPA) (2022-2030) ($MN)
13 Global Cryo-Electron Microscopy Market Outlook, By Other Methods (2022-2030) ($MN)
14 Global Cryo-Electron Microscopy Market Outlook, By Nano Formulations (2022-2030) ($MN)
15 Global Cryo-Electron Microscopy Market Outlook, By Lipid Nanoparticle Formulations (LNFS) (2022-2030) ($MN)
16 Global Cryo-Electron Microscopy Market Outlook, By Metal Oxide Formulations (2022-2030) ($MN)
17 Global Cryo-Electron Microscopy Market Outlook, By Metal Formulations (2022-2030) ($MN)
18 Global Cryo-Electron Microscopy Market Outlook, By Other Nano Formulations (2022-2030) ($MN)
19 Global Cryo-Electron Microscopy Market Outlook, By Voltage (2022-2030) ($MN)
20 Global Cryo-Electron Microscopy Market Outlook, By 300 kV (2022-2030) ($MN)
21 Global Cryo-Electron Microscopy Market Outlook, By 200 kV (2022-2030) ($MN)
22 Global Cryo-Electron Microscopy Market Outlook, By 120 kV (2022-2030) ($MN)
23 Global Cryo-Electron Microscopy Market Outlook, By Technology (2022-2030) ($MN)
24 Global Cryo-Electron Microscopy Market Outlook, By Transmission Electron Microscopy (TEM) (2022-2030) ($MN)
25 Global Cryo-Electron Microscopy Market Outlook, By Scanning Electron Microscopy (SEM) (2022-2030) ($MN)
26 Global Cryo-Electron Microscopy Market Outlook, By Nuclear Magnetic Resonance (NMR) Microscopy (2022-2030) ($MN)
27 Global Cryo-Electron Microscopy Market Outlook, By Other Technologies (2022-2030) ($MN)
28 Global Cryo-Electron Microscopy Market Outlook, By Application (2022-2030) ($MN)
29 Global Cryo-Electron Microscopy Market Outlook, By Life Science Research and Academia (2022-2030) ($MN)
30 Global Cryo-Electron Microscopy Market Outlook, By Cancer Research (2022-2030) ($MN)
31 Global Cryo-Electron Microscopy Market Outlook, By Omics Research (2022-2030) ($MN)
32 Global Cryo-Electron Microscopy Market Outlook, By Pharma and Biotech Manufacturing (2022-2030) ($MN)
33 Global Cryo-Electron Microscopy Market Outlook, By Cell and Gene Therapy (2022-2030) ($MN)
34 Global Cryo-Electron Microscopy Market Outlook, By Pathology (2022-2030) ($MN)
35 Global Cryo-Electron Microscopy Market Outlook, By Preclinical and Clinical Research (2022-2030) ($MN)
36 Global Cryo-Electron Microscopy Market Outlook, By Healthcare/Medical Applications (2022-2030) ($MN)
37 Global Cryo-Electron Microscopy Market Outlook, By Disease Diagnosis and Pathology (2022-2030) ($MN)
38 Global Cryo-Electron Microscopy Market Outlook, By Toxicology Studies (2022-2030) ($MN)
39 Global Cryo-Electron Microscopy Market Outlook, By Material Analysis (2022-2030) ($MN)
40 Global Cryo-Electron Microscopy Market Outlook, By Nanotechnology (2022-2030) ($MN)
41 Global Cryo-Electron Microscopy Market Outlook, By Clinical Trials (2022-2030) ($MN)
42 Global Cryo-Electron Microscopy Market Outlook, By Other Applications (2022-2030) ($MN)
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.
List of Figures
RESEARCH METHODOLOGY
We at ‘Stratistics’ opt for an extensive research approach which involves data mining, data validation, and data analysis. The various research sources include in-house repository, secondary research, competitor’s sources, social media research, client internal data, and primary research.
Our team of analysts prefers the most reliable and authenticated data sources in order to perform the comprehensive literature search. With access to most of the authenticated data bases our team highly considers the best mix of information through various sources to obtain extensive and accurate analysis.
Each report takes an average time of a month and a team of 4 industry analysts. The time may vary depending on the scope and data availability of the desired market report. The various parameters used in the market assessment are standardized in order to enhance the data accuracy.
Data Mining
The data is collected from several authenticated, reliable, paid and unpaid sources and is filtered depending on the scope & objective of the research. Our reports repository acts as an added advantage in this procedure. Data gathering from the raw material suppliers, distributors and the manufacturers is performed on a regular basis, this helps in the comprehensive understanding of the products value chain. Apart from the above mentioned sources the data is also collected from the industry consultants to ensure the objective of the study is in the right direction.
Market trends such as technological advancements, regulatory affairs, market dynamics (Drivers, Restraints, Opportunities and Challenges) are obtained from scientific journals, market related national & international associations and organizations.
Data Analysis
From the data that is collected depending on the scope & objective of the research the data is subjected for the analysis. The critical steps that we follow for the data analysis include:
- Product Lifecycle Analysis
- Competitor analysis
- Risk analysis
- Porters Analysis
- PESTEL Analysis
- SWOT Analysis
The data engineering is performed by the core industry experts considering both the Marketing Mix Modeling and the Demand Forecasting. The marketing mix modeling makes use of multiple-regression techniques to predict the optimal mix of marketing variables. Regression factor is based on a number of variables and how they relate to an outcome such as sales or profits.
Data Validation
The data validation is performed by the exhaustive primary research from the expert interviews. This includes telephonic interviews, focus groups, face to face interviews, and questionnaires to validate our research from all aspects. The industry experts we approach come from the leading firms, involved in the supply chain ranging from the suppliers, distributors to the manufacturers and consumers so as to ensure an unbiased analysis.
We are in touch with more than 15,000 industry experts with the right mix of consultants, CEO's, presidents, vice presidents, managers, experts from both supply side and demand side, executives and so on.
The data validation involves the primary research from the industry experts belonging to:
- Leading Companies
- Suppliers & Distributors
- Manufacturers
- Consumers
- Industry/Strategic Consultants
Apart from the data validation the primary research also helps in performing the fill gap research, i.e. providing solutions for the unmet needs of the research which helps in enhancing the reports quality.
For more details about research methodology, kindly write to us at info@strategymrc.com
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