Epigenetics Market
PUBLISHED: 2023 ID: SMRC23265
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Epigenetics Market

Epigenetics Market Forecasts to 2028 - Global Analysis By Product (Kits & Reagents, Enzymes, Instruments and Accessories, Software and Other Products), Technique (Next-generation sequencing (NGS), PCR & qPCR, Mass Spectrometry, Sonication and Other Techniques), Technology, Application, End User and By Geography

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4.9 (54 reviews)
Published: 2023 ID: SMRC23265

This report covers the impact of COVID-19 on this global market
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Years Covered

2020-2028

Estimated Year Value (2022)

US $1.7 BN

Projected Year Value (2028)

US $5.10 BN

CAGR (2022 - 2028)

20.1%

Regions Covered

North America, Europe, Asia Pacific, South America, and Middle East & Africa

Countries Covered

US, Canada, Mexico, Germany, UK, Italy, France, Spain, Japan, China, India, Australia, New Zealand, South Korea, Rest of Asia Pacific, South America, Argentina, Brazil, Chile, Middle East & Africa, Saudi Arabia, UAE, Qatar, and South Africa

Largest Market

North America

Highest Growing Market

Asia Pacific


According to Stratistics MRC, the Global Epigenetics Market is accounted for $1.7 billion in 2022 and is expected to reach $5.10 billion by 2028 growing at a CAGR of 20.1% during the forecast period. Epigenetics refers to a stream of genetics that involves the study of physiological and cellular trait variations initiated by external or ecological aspects, which turn genes on and off and affect the cellular ability to read the genes without being impacted by changes in genotype. It results in changes in the phenotype of an organism rather than the genotype, where the underlying RNA or DNA sequence remains unchanged. Epigenetic alterations are vital for development as they are dynamic and change as per the surrounding environment's stimuli.

According to WHO, the worldwide population of people aged 65 and up is estimated to grow from 1 billion in the year 2019 to approximately 2.1 billion in 2050.



Market Dynamics:


Driver:

Cancer is becoming more prevalent

The increasing number of epigenetic applications in cancer treatment and other illnesses is expected to drive the global epigenetics business forward. Numerous research institutes are thoroughly investigating epigenetics in order to develop necessary vaccines and drugs for abnormalities that do not currently have effective therapies assigned to them because it has been shown to be highly effective in treating specific types of cancer. Organizations such as the National Cancer Institute, Human Epigenome Consortium, and National Institute of Health have lobbied for more epigenetics investment not only for research but also for commercialization, which is expected to promote global expansion over the projected period.

Restraint:

Limited applications of epigenomic data in toxicology

Toxicology has seen the limited application of epigenomic data an incomplete understanding of epigenomic variability has led to restricted knowledge on risk assessment across different tissue types and populations. This requires developing new solutions to ensure a comprehensive understanding of epigenetic mechanisms, resulting in detailed epigenomic variation mapping. A key obstacle to the application of epigenomic analysis in toxicology is the lack of identification and consensus on a normal epigenome for all tissues and cell types, which are projected to impede the fog computing market's growth.

Opportunity:

Utilization in personalized pharmaceuticals

Patients are given genomic or personalized medicines after obtaining genetic data as well as associated information such as levels of RNA, proteins, and other metabolites, which are critical aspects in medical decision-making for personalized medicine. Genomic methods such as transcriptomics, finding DNA sequence variants, metabolomics, and proteomics are useful for accurate disease management and prediction. These tactics are powerful tools for bridging the gap between epigenetics and personalized medicine. Furthermore, information from a specific genome sequence, as well as the related biomarkers, is essential for personalized and genomic medicines to be identified, which is another critical reason expected to aid the expansion of the epigenetics market.

Threat:

Lack of standardization

Epigenetics research involves a wide range of experimental protocols, including sample preparation, DNA extraction, bisulfite conversion and data analysis. Without standardized protocols, there can be variations in methodologies and techniques used across different laboratories and research groups. These inconsistencies can lead to difficulties in comparing and replicating results, reducing the reliability and reproducibility of findings. Standardization is crucial for the development of reliable and validated epigenetic biomarkers. Biomarkers play a critical role in disease diagnosis, prognosis, and treatment selection. Inconsistent protocols and methodologies can lead to variations in biomarker discovery and validation, making it challenging to establish robust and clinically relevant biomarkers, which becomes a threat to market growth.

Covid-19 Impact:

COVID-19 has significantly impacted the epigenetics market growth due to the importance of epigenetics in COVID-19 research. Epigenetic modifications may play an important role in the beginning of corona virus illness consequences. Despite the fact that several treatment alternatives are being researched, more research is urgently required to develop a viable vaccine or safer chemotherapeutic drugs, including epigenetic treatments, to combat this viral pandemic and provide before and post-exposure COVID-19 prophylaxis. This will result in increased use of epigenetics in the discovery of COVID-19 infection therapeutics, which is projected to fuel market growth during the forecast period.

The kits & reagents segment is expected to be the largest during the forecast period

The kits & reagents segment has generated the greatest revenue share in the market, owing to the increased development of simple-to-use, low-cost, and advanced epigenetic kits and reagents. This is aided by the exponential increase in the number of epigenetic research papers conducted over the years. Antibodies, ChiP-seq kits, bisulfite conversion kits, whole genome amplification kits, 5-hmC and 5-mC analysis kits, histones, and other kits & reagents are further subdivided. Epigenetics software tools aid in the investigation of complicated epigenetic alterations, thereby boosting market growth.

The Next-generation sequencing (NGS) segment is expected to have the highest CAGR during the forecast period

Next-generation sequencing (NGS) segment is expected to witness fastest growth and expected to have the highest CAGR in the market over the forecast period. NGS techniques can be integrated with other omics technologies, such as genomics, transcriptomics, and proteomics, to enable comprehensive multi-omics analysis. This integration allows researchers to gain a holistic view of the interplay between different layers of molecular regulation, including epigenetic modifications, and provides valuable insights into complex biological processes and disease mechanisms, which is a crucial factor fostering the expansion of the global market.

Region with largest share:

The North American Epigenetics market dominated the global market, and it is anticipated that this dominance will continue over the course of the forecast period. North America, particularly the United States, has a robust research infrastructure and funding mechanisms that support epigenetics research. Renowned research institutions such as Harvard University, Massachusetts Institute of Technology (MIT), and University of California, San Francisco (UCSF) are actively involved in epigenetics studies. This focus on research and development fuels innovation and drives the growth of the market.

Region with highest CAGR:

Asia Pacific is predicted to grow at the highest CAGR in this Epigenetics market over the forecast period. The Asia Pacific region has a high burden of diseases such as cancer, cardiovascular disorders, and neurological conditions. Epigenetic diagnostics offer the potential for early detection, prognosis, and personalized treatment options. As a result, there is a growing demand for epigenetic testing services and diagnostic products in the region. Companies are developing epigenetic biomarker-based tests for various diseases to cater to this demand. The combination of increasing research activities, investments from the biotechnology and pharmaceutical sectors, government support, and the rising adoption of precision medicine contribute to the development and expansion of the epigenetics market in the region.



Key players in the market:


Some of the key players in Epigenetics Market include Abcam PLC, Active Motif, Inc., Agilent Technologies, Inc., Bio-Rad Laboratories, Creative Biogene, Diagenode, Dovetail Genomics LLC., Eisai Co. Ltd., Element Biosciences, Inc., Epigentek Group INC., F. Hoffmann-La Roche Ltd, Hologic Inc., Illumina Inc., Merck & Co. Inc., New England Biolabs, Novartis AG, PerkinElmer, Qiagen NV, Roche Diagnostics, Thermo Fisher Scientific, Inc., ValiRx Plc. and Zymo Research Corporation.

Key Developments:

In February 2022, Zenith Epigenetics Ltd. reported the dosing of the first patient with a combination of ZEN-3694 (BET inhibitor) + Bristol Myers Squibb’s PD-1 immune checkpoint inhibitor OPDIVO and YERVOY in a National Cancer Institute (NCI), part of the National Institutes of Health.

In September 2022, PacBio introduced DNA methylation capabilities via its product line, Sequel, in the US. Introducing this feature to the Sequel systems is expected to extend the accessibility of epigenomes via HiFi sequencing developed by the company.

In December 2021, Element Biosciences, Inc., developer of a new and disruptive DNA sequencing platform, entered a partnership with Dovetail Genomics to demonstrate the value and performance of Dovetail’s proximity ligation-based-based next-generation sequencing (NGS) library prep solutions on Element’s AVITI System.

Products Covered:
• Kits & Reagents
• Enzymes
• Instruments and Accessories
• Software
• Other Products

Techniques Covered:
• Next-generation sequencing (NGS)
• PCR & qPCR
• Mass Spectrometry
• Sonication
• Other Techniques

Technologies Covered:
• DNA Methylation
• Histone Modifications
• Acetylation
• Phosphorylation
• Large non - coding RNA
• Other Technologies

Applications Covered:
• Oncology
• Non-Oncology
• Metabolic Diseases
• Immunology
• Developmental Biology
• Cardiovascular Diseases
• Other Applications

End Users Covered:
• Academic
• Research Institutes
• Pharmaceutical
• Biotechnology Companies
• Hospitals
• Clinics

Regions Covered:
• North America
o US
o Canada
o Mexico
• Europe
o Germany
o UK
o Italy
o France
o Spain
o Rest of Europe
• Asia Pacific
o Japan
o China
o India
o Australia
o New Zealand
o South Korea
o Rest of Asia Pacific
• South America
o Argentina
o Brazil
o Chile
o Rest of South America
• Middle East & Africa
o Saudi Arabia
o UAE
o Qatar
o South Africa
o Rest of Middle East & Africa

What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2020, 2021, 2022, 2025, and 2028
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements

Free Customization Offerings:
All the customers of this report will be entitled to receive one of the following free customization options:
• Company Profiling
o Comprehensive profiling of additional market players (up to 3)
o SWOT Analysis of key players (up to 3)
• Regional Segmentation
o Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
• Competitive Benchmarking
Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances

Table of Contents

1 Executive Summary

2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions

3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 Technology Analysis
3.8 Application Analysis
3.9 End User Analysis
3.10 Emerging Markets
3.11 Impact of Covid-19

4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry

5 Global Epigenetics Market, By Product
5.1 Introduction
5.2 Kits & Reagents
5.2.1 Antibodies
5.2.2 ChiP-seq Kits
5.2.3 Bisulfite Conversion Kits
5.2.4 Whole Genome Amplification Kits
5.2.5 5-hmC and 5-mC Analysis Kits
5.2.6 Histones
5.3 Enzymes
5.3.1 DNA-modifying Enzymes
5.3.2 Protein-modifying Enzymes
5.4 Instruments and Accessories
5.5 Software
5.6 Other Products

6 Global Epigenetics Market, By Technique
6.1 Introduction
6.2 Next-generation sequencing (NGS)
6.3 PCR & qPCR
6.4 Mass Spectrometry
6.5 Sonication
6.6 Other Techniques

7 Global Epigenetics Market, By Technology
7.1 Introduction
7.2 DNA Methylation
7.3 Histone Modifications
7.4 Acetylation
7.5 Phosphorylation
7.6 Large non - coding RNA
7.7 Other Technologies

8 Global Epigenetics Market, By Application
8.1 Introduction
8.2 Oncology
8.2.1 Solid Tumors
8.2.2 Liquid Tumors
8.3 Non-Oncology
8.4 Metabolic Diseases
8.5 Immunology
8.6 Developmental Biology
8.7 Cardiovascular Diseases
8.8 Other Applications

9 Global Epigenetics Market, By End User
9.1 Introduction
9.2 Academic
9.3 Research Institutes
9.4 Pharmaceutical
9.5 Biotechnology Companies
9.6 Hospitals
9.7 Clinics

10 Global Epigenetics Market, By Geography
10.1 Introduction
10.2 North America
10.2.1 US
10.2.2 Canada
10.2.3 Mexico
10.3 Europe
10.3.1 Germany
10.3.2 UK
10.3.3 Italy
10.3.4 France
10.3.5 Spain
10.3.6 Rest of Europe
10.4 Asia Pacific
10.4.1 Japan
10.4.2 China
10.4.3 India
10.4.4 Australia
10.4.5 New Zealand
10.4.6 South Korea
10.4.7 Rest of Asia Pacific
10.5 South America
10.5.1 Argentina
10.5.2 Brazil
10.5.3 Chile
10.5.4 Rest of South America
10.6 Middle East & Africa
10.6.1 Saudi Arabia
10.6.2 UAE
10.6.3 Qatar
10.6.4 South Africa
10.6.5 Rest of Middle East & Africa

11 Key Developments
11.1 Agreements, Partnerships, Collaborations and Joint Ventures
11.2 Acquisitions & Mergers
11.3 New Product Launch
11.4 Expansions
11.5 Other Key Strategies

12 Company Profiling
12.1 Abcam PLC
12.2 Active Motif, Inc.
12.3 Agilent Technologies, Inc.
12.4 Bio-Rad Laboratories
12.5 CREATIVE BIOGENE
12.6 Diagenode
12.7 Dovetail Genomics LLC.
12.8 Eisai Co. Ltd.
12.9 Element Biosciences, Inc.
12.10 EPIGENTEK GROUP INC.
12.11 F. Hoffmann-La Roche Ltd
12.12 Hologic Inc.
12.13 Illumina Inc.
12.14 Merck & Co. Inc.
12.15 New England Biolabs
12.16 Novartis AG
12.17 PerkinElmer
12.18 Qiagen NV
12.19 Roche Diagnostics
12.20 Thermo Fisher Scientific, Inc.
12.21 ValiRx Plc.
12.22 Zymo Research Corporation

List of Tables
1 Global Epigenetics Market Outlook, By Region (2020-2028) ($MN)
2 Global Epigenetics Market Outlook, By Product (2020-2028) ($MN)
3 Global Epigenetics Market Outlook, By Kits & Reagents (2020-2028) ($MN)
4 Global Epigenetics Market Outlook, By Antibodies (2020-2028) ($MN)
5 Global Epigenetics Market Outlook, By ChiP-seq Kits (2020-2028) ($MN)
6 Global Epigenetics Market Outlook, By Bisulfite Conversion Kits (2020-2028) ($MN)
7 Global Epigenetics Market Outlook, By Whole Genome Amplification Kits (2020-2028) ($MN)
8 Global Epigenetics Market Outlook, By 5-hmC and 5-mC Analysis Kits (2020-2028) ($MN)
9 Global Epigenetics Market Outlook, By Histones (2020-2028) ($MN)
10 Global Epigenetics Market Outlook, By Enzymes (2020-2028) ($MN)
11 Global Epigenetics Market Outlook, By DNA-modifying Enzymes (2020-2028) ($MN)
12 Global Epigenetics Market Outlook, By Protein-modifying Enzymes (2020-2028) ($MN)
13 Global Epigenetics Market Outlook, By Instruments and Accessories (2020-2028) ($MN)
14 Global Epigenetics Market Outlook, By Software (2020-2028) ($MN)
15 Global Epigenetics Market Outlook, By Other Products (2020-2028) ($MN)
16 Global Epigenetics Market Outlook, By Technique (2020-2028) ($MN)
17 Global Epigenetics Market Outlook, By Next-generation sequencing (NGS) (2020-2028) ($MN)
18 Global Epigenetics Market Outlook, By PCR & qPCR (2020-2028) ($MN)
19 Global Epigenetics Market Outlook, By Mass Spectrometry (2020-2028) ($MN)
20 Global Epigenetics Market Outlook, By Sonication (2020-2028) ($MN)
21 Global Epigenetics Market Outlook, By Other Techniques (2020-2028) ($MN)
22 Global Epigenetics Market Outlook, By Technology (2020-2028) ($MN)
23 Global Epigenetics Market Outlook, By DNA Methylation (2020-2028) ($MN)
24 Global Epigenetics Market Outlook, By Histone Modifications (2020-2028) ($MN)
25 Global Epigenetics Market Outlook, By Acetylation (2020-2028) ($MN)
26 Global Epigenetics Market Outlook, By Phosphorylation (2020-2028) ($MN)
27 Global Epigenetics Market Outlook, By Large non - coding RNA (2020-2028) ($MN)
28 Global Epigenetics Market Outlook, By Other Technologies (2020-2028) ($MN)
29 Global Epigenetics Market Outlook, By Application (2020-2028) ($MN)
30 Global Epigenetics Market Outlook, By Oncology (2020-2028) ($MN)
31 Global Epigenetics Market Outlook, By Solid Tumors (2020-2028) ($MN)
32 Global Epigenetics Market Outlook, By Liquid Tumors (2020-2028) ($MN)
33 Global Epigenetics Market Outlook, By Non-Oncology (2020-2028) ($MN)
34 Global Epigenetics Market Outlook, By Metabolic Diseases (2020-2028) ($MN)
35 Global Epigenetics Market Outlook, By Immunology (2020-2028) ($MN)
36 Global Epigenetics Market Outlook, By Developmental Biology (2020-2028) ($MN)
37 Global Epigenetics Market Outlook, By Cardiovascular Diseases (2020-2028) ($MN)
38 Global Epigenetics Market Outlook, By Other Applications (2020-2028) ($MN)
39 Global Epigenetics Market Outlook, By End User (2020-2028) ($MN)
40 Global Epigenetics Market Outlook, By Academic (2020-2028) ($MN)
41 Global Epigenetics Market Outlook, By Research Institutes (2020-2028) ($MN)
42 Global Epigenetics Market Outlook, By Pharmaceutical (2020-2028) ($MN)
43 Global Epigenetics Market Outlook, By Biotechnology Companies (2020-2028) ($MN)
44 Global Epigenetics Market Outlook, By Hospitals (2020-2028) ($MN)
45 Global Epigenetics Market Outlook, By Clinics (2020-2028) ($MN)

Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.

List of Figures

RESEARCH METHODOLOGY


Research Methodology

We at Stratistics opt for an extensive research approach which involves data mining, data validation, and data analysis. The various research sources include in-house repository, secondary research, competitor’s sources, social media research, client internal data, and primary research.

Our team of analysts prefers the most reliable and authenticated data sources in order to perform the comprehensive literature search. With access to most of the authenticated data bases our team highly considers the best mix of information through various sources to obtain extensive and accurate analysis.

Each report takes an average time of a month and a team of 4 industry analysts. The time may vary depending on the scope and data availability of the desired market report. The various parameters used in the market assessment are standardized in order to enhance the data accuracy.

Data Mining

The data is collected from several authenticated, reliable, paid and unpaid sources and is filtered depending on the scope & objective of the research. Our reports repository acts as an added advantage in this procedure. Data gathering from the raw material suppliers, distributors and the manufacturers is performed on a regular basis, this helps in the comprehensive understanding of the products value chain. Apart from the above mentioned sources the data is also collected from the industry consultants to ensure the objective of the study is in the right direction.

Market trends such as technological advancements, regulatory affairs, market dynamics (Drivers, Restraints, Opportunities and Challenges) are obtained from scientific journals, market related national & international associations and organizations.

Data Analysis

From the data that is collected depending on the scope & objective of the research the data is subjected for the analysis. The critical steps that we follow for the data analysis include:

  • Product Lifecycle Analysis
  • Competitor analysis
  • Risk analysis
  • Porters Analysis
  • PESTEL Analysis
  • SWOT Analysis

The data engineering is performed by the core industry experts considering both the Marketing Mix Modeling and the Demand Forecasting. The marketing mix modeling makes use of multiple-regression techniques to predict the optimal mix of marketing variables. Regression factor is based on a number of variables and how they relate to an outcome such as sales or profits.


Data Validation

The data validation is performed by the exhaustive primary research from the expert interviews. This includes telephonic interviews, focus groups, face to face interviews, and questionnaires to validate our research from all aspects. The industry experts we approach come from the leading firms, involved in the supply chain ranging from the suppliers, distributors to the manufacturers and consumers so as to ensure an unbiased analysis.

We are in touch with more than 15,000 industry experts with the right mix of consultants, CEO's, presidents, vice presidents, managers, experts from both supply side and demand side, executives and so on.

The data validation involves the primary research from the industry experts belonging to:

  • Leading Companies
  • Suppliers & Distributors
  • Manufacturers
  • Consumers
  • Industry/Strategic Consultants

Apart from the data validation the primary research also helps in performing the fill gap research, i.e. providing solutions for the unmet needs of the research which helps in enhancing the reports quality.


For more details about research methodology, kindly write to us at info@strategymrc.com

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